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Information Journal Paper

Title

COMPARISON OF EXPRESSION OF GROWTH HORMONE-RELEASING HORMONE AND ITS RECEPTOR SPLICE VARIANT 1 IN DIFFERENT STAGES OF ENDOMETRIOSIS

Pages

  33-38

Abstract

 Background: The present study aims to explore the significance of the expression of growth hormone-releasing hormone (GHRH) and its receptor SPLICE VARIANT 1 (GHRH-SV1) in ENDOMETRIOSIS (EM).Materials and Methods: In this research paper 80 EM patients who received treatment between March 2009 and September 2010 were selected, among which 20 were in stages I, II, III and IV respectively.50 non-EM patients who underwent hysterectomy because of myoma during the same period comprised the control group. GHRH, GHRH-SV1 and their corresponding mRNA expression in eutopic endometrium and endometriotic tissue as well as ectopic endometrium were detected using immunohistochemical streptavidin-peroxidase (SP) and RT-PCR methods. Analysis of Variance (ANOVA) with Tukey Post Hoc test was used for data analysis and p<0.05 was considered significant.Results: GHRH, GHRH-SV1 and their corresponding mRNA were expressed in eutopic endometrium and endometriotic tissue as well as ectopic endometrium. The mean optical density (OD) values of the GHRH and GHRH-SV1 expression in the experimental group were significantly higher than those in the normal group (p<0.05), and the relative intensity (RI) of GHRH mRNA and GHRH-SV1 mRNA expression in the experimental group was also significantly higher (p<0.05). The mean OD values of the GHRH and GHRH-SV1 expression showed significant differences among endometriotic tissue at different stages of EM (p<0.05), and the RI of GHRH and GHRH-SV1 mRNA expression also showed significant differences (p<0.05).Conclusion: GHRH and GHRH-SV1 expression levels differ significantly at different stages of ENDOMETRIOSIS.

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    APA: Copy

    WANG, QIMING, WANG, YUEYUE, XIANHU, FU, & HUANG, YONG. (2013). COMPARISON OF EXPRESSION OF GROWTH HORMONE-RELEASING HORMONE AND ITS RECEPTOR SPLICE VARIANT 1 IN DIFFERENT STAGES OF ENDOMETRIOSIS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 7(1), 33-38. SID. https://sid.ir/paper/305393/en

    Vancouver: Copy

    WANG QIMING, WANG YUEYUE, XIANHU FU, HUANG YONG. COMPARISON OF EXPRESSION OF GROWTH HORMONE-RELEASING HORMONE AND ITS RECEPTOR SPLICE VARIANT 1 IN DIFFERENT STAGES OF ENDOMETRIOSIS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2013;7(1):33-38. Available from: https://sid.ir/paper/305393/en

    IEEE: Copy

    QIMING WANG, YUEYUE WANG, FU XIANHU, and YONG HUANG, “COMPARISON OF EXPRESSION OF GROWTH HORMONE-RELEASING HORMONE AND ITS RECEPTOR SPLICE VARIANT 1 IN DIFFERENT STAGES OF ENDOMETRIOSIS,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 7, no. 1, pp. 33–38, 2013, [Online]. Available: https://sid.ir/paper/305393/en

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