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Information Journal Paper

Title

POSSIBLE ROLE OF AUTOIMMUNITY IN PATIENTS WITH PREMATURE OVARIAN INSUFFICIENCY

Pages

  281-290

Abstract

 Background: To evaluate the involvement of immune abnormality in patients with idiopathic PREMATURE OVARIAN INSUFFICIENCY (POI). In addition to the known etiology, autoimmune disorders may be a pathologic mechanism for POI.Materials and Methods: Our study was a prospective controlled trial. Twenty women with POI, reasons other than autoimmune excluded, were enrolled in this study. The control group consisted of 17 healthy women. In both groups, family and personal history were taken and the levels of follicle stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, prolactin, anti-Mullerian hormone, inhibin B, antithyroglobulin and antithyroid peroxidase antibodies were determined. Anti-ovarian antibodies and subpopulations of peripheral blood T-lymhocytes were also determined.Results: Participants in the study group exhibited hypergonadotropichypogonadism, while high levels of follicle stimulating hormone and low levels of inhibin B and anti- Mullerian hormone were observed. In 16 (80%) patients, POI was associated in their personal and familial history with another autoimmune disease. Fifty percent of patients presented highly elevated antithyroid antibodies. The lymphocyte subset, especially B cells, was significantly higher (p=0.014), and peripheral regulatory lymphocytes CD25+high were significantly lower (p=0.015) in the study group than in the control group. Anti-ovarian antibodies were detected in 20% of patients with POI.Conclusion: We presume that the presence of anti-ovarian antibodies together with abnormalities of cellular immunity may in some cases potentially represent the involvement of an autoimmune mechanism in idiopathic POI.

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    APA: Copy

    POGACNIK, RENATA KOSIR, VRTOVEC, HELENA MEDEN, VIZJAK, ALENKA, LEVICNIK, ALENKA URSULA, SLABE, NINA, & IHAN, ALOJZ. (2014). POSSIBLE ROLE OF AUTOIMMUNITY IN PATIENTS WITH PREMATURE OVARIAN INSUFFICIENCY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 7(4), 281-290. SID. https://sid.ir/paper/305436/en

    Vancouver: Copy

    POGACNIK RENATA KOSIR, VRTOVEC HELENA MEDEN, VIZJAK ALENKA, LEVICNIK ALENKA URSULA, SLABE NINA, IHAN ALOJZ. POSSIBLE ROLE OF AUTOIMMUNITY IN PATIENTS WITH PREMATURE OVARIAN INSUFFICIENCY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2014;7(4):281-290. Available from: https://sid.ir/paper/305436/en

    IEEE: Copy

    RENATA KOSIR POGACNIK, HELENA MEDEN VRTOVEC, ALENKA VIZJAK, ALENKA URSULA LEVICNIK, NINA SLABE, and ALOJZ IHAN, “POSSIBLE ROLE OF AUTOIMMUNITY IN PATIENTS WITH PREMATURE OVARIAN INSUFFICIENCY,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 7, no. 4, pp. 281–290, 2014, [Online]. Available: https://sid.ir/paper/305436/en

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