مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

CD107A EXPRESSION AND IFN-γ PRODUCTION AS MARKERS FOR EVALUATION OF CYTOTOXIC CD3+ CD8+CYTOTOXIC T LYMPHOCYTE, CMV, RECURRENT ABORTION T CELL RESPONSE TO CMV ANTIGEN IN WOMEN WITH RECURRENT SPONTANEOUS ABORTION

Pages

  323-330

Abstract

 Background: Some evidence has shown a relationship between primary human cytomegalovirus (CMV) infection and pregnancy loss. The impact of CMV infection reactivation during pregnancy on adverse pregnancy outcomes is not completely understood. It is proposed that altered immune response, and therefore, recurrence or reactivation of latent CMV infection may relate to recurrent spontaneous abortion (RSA), however, few data are available in this regard. To find out about any cell mediated defect and reactivation of latent CMV infection in women with RPL, cellular immunity to the virus has been evaluated by specific CYTOTOXIC T LYMPHOCYTE (CTL) response to CMV.Materials and Methods: In a case control study, CTL CD107a expression and intercellular IFN-g production in response to CMV pp65 antigen and staphylococcus enterotoxin B (SEB) in women with RSA were assessed by flow cytometric analysis. Forty-four cases with history of recurrent pregnancy and forty-four controls with history of successful pregnancies were included. The FACSCaliber flow cytometer were used for analysis.Results: No significant difference was observed between CD107a expression and IFN-g production in response to CMV PP65 antigen in RPL patients and control group. However, the cytotoxic response to SEB antigen in patients with RPL was significantly lower than control group (p=0.042).Conclusion: The results of this study show that impaired CD107a expression and IFN-g production as CTL response to CMV does not appear to be a major contributing and immune incompetence factor in patients with RPL, but cytotoxic T cell response defect to other antigens requires to be assessed further in these patients.

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    APA: Copy

    TAROKHIAN, BATOUL, SHERKAT, ROYA, NASR ESFAHANI, MOHAMMA HOSSEIN, ADIB, MINOO, KIANI ESFAHANI, ABBAS, & ATAEI, BEHROOZ. (2014). CD107A EXPRESSION AND IFN-γ PRODUCTION AS MARKERS FOR EVALUATION OF CYTOTOXIC CD3+ CD8+CYTOTOXIC T LYMPHOCYTE, CMV, RECURRENT ABORTION T CELL RESPONSE TO CMV ANTIGEN IN WOMEN WITH RECURRENT SPONTANEOUS ABORTION. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 7(4), 323-330. SID. https://sid.ir/paper/305437/en

    Vancouver: Copy

    TAROKHIAN BATOUL, SHERKAT ROYA, NASR ESFAHANI MOHAMMA HOSSEIN, ADIB MINOO, KIANI ESFAHANI ABBAS, ATAEI BEHROOZ. CD107A EXPRESSION AND IFN-γ PRODUCTION AS MARKERS FOR EVALUATION OF CYTOTOXIC CD3+ CD8+CYTOTOXIC T LYMPHOCYTE, CMV, RECURRENT ABORTION T CELL RESPONSE TO CMV ANTIGEN IN WOMEN WITH RECURRENT SPONTANEOUS ABORTION. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2014;7(4):323-330. Available from: https://sid.ir/paper/305437/en

    IEEE: Copy

    BATOUL TAROKHIAN, ROYA SHERKAT, MOHAMMA HOSSEIN NASR ESFAHANI, MINOO ADIB, ABBAS KIANI ESFAHANI, and BEHROOZ ATAEI, “CD107A EXPRESSION AND IFN-γ PRODUCTION AS MARKERS FOR EVALUATION OF CYTOTOXIC CD3+ CD8+CYTOTOXIC T LYMPHOCYTE, CMV, RECURRENT ABORTION T CELL RESPONSE TO CMV ANTIGEN IN WOMEN WITH RECURRENT SPONTANEOUS ABORTION,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 7, no. 4, pp. 323–330, 2014, [Online]. Available: https://sid.ir/paper/305437/en

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