مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

MORPHINE ATTENUATES TESTOSTERONE RESPONSE TO CENTRAL INJECTION OF KISSPEPTIN IN MALE RATS

Pages

  215-220

Abstract

 Background: KISSPEPTIN and NALOXONE stimulate the reproductive axis while MORPHINE inhibits its function. We have investigated the effect of central injection of KISSPEPTIN-10 on mean plasma TESTOSTERONE concentration in MORPHINE or NALOXONE pretreated rats. Materials and Methods: In this experimental study, 60 male Wistar rats that were divided into 12 groups (n=5 per group) received saline, KISSPEPTIN (1 nmol, ICV), NALOXONE (2 mg/kg, subcutaneously), MORPHINE (5 or 10 mg/kg, sc) or co-administrations of KISSPEPTIN, MORPHINE and NALOXONE at 09:00-09:30. In the co-administrated groups, KISSPEPTIN was injected 15 minutes following MORPHINE or NALOXONE injections. Blood samples were collected 60 minutes following injections via the tail vein. Plasma TESTOSTERONE concentration was measured by a rat TESTOSTERONE ELISA kit.Results: Central injection of KISSPEPTIN or subcutaneous injection of NALOXONE significantly increased the mean plasma TESTOSTERONE concentration compared to saline while subcutaneous injections of different doses of MORPHINE (5 or 10 mg/kg) significantly decreased TESTOSTERONE compared to saline. The results revealed that MORPHINE significantly attenuated the TESTOSTERONE increase after KISSPEPTIN injection compared to KISSPEPTIN while a stimulatory additive effect was observed in the KISSPEPTIN/naloxone group compared to either NALOXONE or KISSPEPTIN.Conclusion: MORPHINE and KISSPEPTIN systems may interact with each other to control the hypothalamic-pituitary-gonadal (HPG) axis.

Cites

References

Cite

APA: Copy

MAHMOUDI, FARIBA, KHAZALI, HOMAYOUN, & JANAHMADI, MAHYAR. (2014). MORPHINE ATTENUATES TESTOSTERONE RESPONSE TO CENTRAL INJECTION OF KISSPEPTIN IN MALE RATS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 8(2), 215-220. SID. https://sid.ir/paper/305743/en

Vancouver: Copy

MAHMOUDI FARIBA, KHAZALI HOMAYOUN, JANAHMADI MAHYAR. MORPHINE ATTENUATES TESTOSTERONE RESPONSE TO CENTRAL INJECTION OF KISSPEPTIN IN MALE RATS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2014;8(2):215-220. Available from: https://sid.ir/paper/305743/en

IEEE: Copy

FARIBA MAHMOUDI, HOMAYOUN KHAZALI, and MAHYAR JANAHMADI, “MORPHINE ATTENUATES TESTOSTERONE RESPONSE TO CENTRAL INJECTION OF KISSPEPTIN IN MALE RATS,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 8, no. 2, pp. 215–220, 2014, [Online]. Available: https://sid.ir/paper/305743/en

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