THE 763C>G POLYMORPHISM OF THE SECRETORY PLA2IIA GENE IS ASSOCIATED WITH ENDOMETRIOSIS IN IRANIAN WOMEN

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SAHMANI MEHDI; DARABI MASOUD; DARABI MARYAM; DABAGHI TALAAT; ALIZADEH SAFAR ALI; NAJAFIPOUR REZA

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Journal: International Journal of Fertility & Sterility Year:2015 | Volume:8 | Issue:4 Page(s): 437-444

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Title

THE 763C>G POLYMORPHISM OF THE SECRETORY PLA2IIA GENE IS ASSOCIATED WITH ENDOMETRIOSIS IN IRANIAN WOMEN

Author(s)

Keywords

ENDOMETRIOSIS

POLYMORPHISM GENETIC

PLA2G2A

Abstract

Background: ENDOMETRIOSIS is a chronic gynecological disease resulting from complex interactions between genetic, hormonal, environmental and oxidative stress and intrinsic inflammatory components. The aim of this study was to investigate the potential association of the 763C>G polymorphism in the secretory phospholipase A2 group IIa gene (PLA2G2A) with the risk of ENDOMETRIOSIS in Iranian women.Materials and Methods: Ninety seven patients with ENDOMETRIOSIS along with 107 women who were negative for ENDOMETRIOSIS after laparoscopy and laparatomy, and served as the control group, were enrolled for this cross-sectional study. Samples were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method.Results: Multivariate analysis was used to examine the association between the risk of ENDOMETRIOSIS and the763C>G polymorphism of PLA2G2A. Genotype distributions of PLA-2G2A were significantly different between patients and the controls (p<0.001, OR=0.22, 95% CI=0.21-0.39). Correlation analysis showed that there was a significant association between the normal homozygous genotype and susceptibility to ENDOMETRIOSIS (p<0.001).Conclusion: The present study suggests that the 763C>G polymorphism of PLA2G2A plays an important role as an independent factor in the risk of ENDOMETRIOSIS in Iranian women.

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APA: Copy

SAHMANI, MEHDI, DARABI, MASOUD, DARABI, MARYAM, DABAGHI, TALAAT, ALIZADEH, SAFAR ALI, & NAJAFIPOUR, REZA. (2015). THE 763C>G POLYMORPHISM OF THE SECRETORY PLA2IIA GENE IS ASSOCIATED WITH ENDOMETRIOSIS IN IRANIAN WOMEN. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 8(4), 437-444. SID. https://sid.ir/paper/305774/en

Vancouver: Copy

SAHMANI MEHDI, DARABI MASOUD, DARABI MARYAM, DABAGHI TALAAT, ALIZADEH SAFAR ALI, NAJAFIPOUR REZA. THE 763C>G POLYMORPHISM OF THE SECRETORY PLA2IIA GENE IS ASSOCIATED WITH ENDOMETRIOSIS IN IRANIAN WOMEN. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2015;8(4):437-444. Available from: https://sid.ir/paper/305774/en

IEEE: Copy

MEHDI SAHMANI, MASOUD DARABI, MARYAM DARABI, TALAAT DABAGHI, SAFAR ALI ALIZADEH, and REZA NAJAFIPOUR, “THE 763C>G POLYMORPHISM OF THE SECRETORY PLA2IIA GENE IS ASSOCIATED WITH ENDOMETRIOSIS IN IRANIAN WOMEN,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 8, no. 4, pp. 437–444, 2015, [Online]. Available: https://sid.ir/paper/305774/en

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