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Information Journal Paper

Title

THE EXPRESSION OF THE AUTOPHAGY GENE BECLIN-1 MRNA AND PROTEIN IN ECTOPIC AND EUTOPIC ENDOMETRIUM OF PATIENTS WITH ENDOMETRIOSIS

Pages

  429-436

Abstract

 Background: To investigate the expression of BECLIN-1 mRNA and protein in eutopic and ectopic endometrium of women with and without ENDOMETRIOSIS, and evaluate the association of BECLIN-1 protein expression and serum CA125 levels in the ENDOMETRIOSIS group due to CA125 being a well-known biomarker of ENDOMETRIOSIS.Materials and Methods: The expression levels (mean±SD) of the mRNA and protein of BECLIN-1 were examined in uterine endometria from 26 women without ENDOMETRIOSIS and in eutopic and ectopic endometria from 26 ENDOMETRIOSIS patients through experimental study, as reverse transcription PCR and Western-blotting assays. Serum CA125 levels in the ENDOMETRIOSIS and control groups were compared and the correlation between BECLIN-1 protein expression and serum CA125 was evaluated in the ENDOMETRIOSIS group.Results: Both eutopic (0.12±0.04, 1.25±0.42) and ectopic (0.12±0.05, 1.09±0.50) endometriotic tissue from 26 women with ENDOMETRIOSIS expressed significantly lower levels of BECLIN-1 mRNA and protein than endometrium from 26 normal women (0.15±0.02, 1.67±0.44) (p<0.05). Serum CA125 levels were found to be significantly higher in the ENDOMETRIOSIS group (p<0.05). In addition, BECLIN-1 protein expression of eutopic endometria in patients with ENDOMETRIOSIS was negatively correlated with serum CA125 (r=-0.57, p<0.01).Conclusion: The present study strongly suggests that BECLIN-1 may play a role in the formation and progression of ENDOMETRIOSIS.

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    Cite

    APA: Copy

    ZHANG, LONGYU, LIU, YING, XU, YUPING, WU, HUAN, WEI, ZHAOLIAN, & CAO, YUNXIA. (2015). THE EXPRESSION OF THE AUTOPHAGY GENE BECLIN-1 MRNA AND PROTEIN IN ECTOPIC AND EUTOPIC ENDOMETRIUM OF PATIENTS WITH ENDOMETRIOSIS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 8(4), 429-436. SID. https://sid.ir/paper/305775/en

    Vancouver: Copy

    ZHANG LONGYU, LIU YING, XU YUPING, WU HUAN, WEI ZHAOLIAN, CAO YUNXIA. THE EXPRESSION OF THE AUTOPHAGY GENE BECLIN-1 MRNA AND PROTEIN IN ECTOPIC AND EUTOPIC ENDOMETRIUM OF PATIENTS WITH ENDOMETRIOSIS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2015;8(4):429-436. Available from: https://sid.ir/paper/305775/en

    IEEE: Copy

    LONGYU ZHANG, YING LIU, YUPING XU, HUAN WU, ZHAOLIAN WEI, and YUNXIA CAO, “THE EXPRESSION OF THE AUTOPHAGY GENE BECLIN-1 MRNA AND PROTEIN IN ECTOPIC AND EUTOPIC ENDOMETRIUM OF PATIENTS WITH ENDOMETRIOSIS,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 8, no. 4, pp. 429–436, 2015, [Online]. Available: https://sid.ir/paper/305775/en

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