مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

540
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

227
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

EXPRESSION AND DISTRIBUTION OF CALCIUM-BINDING PROTEIN S100P IN HUMAN PLACENTA DURING PREGNANCY

Pages

  445-452

Abstract

 Background: S100P is a member of the S100 family of calcium-binding proteins, and it participates in pathophysiological events, such as tumor growth and invasion.Based on the striking similarities between TROPHOBLAST cells and tumor cells with regard to proliferative and invasive properties, we raised the question of whether and how S100P expresses in TROPHOBLAST cells during development. This study aimed to investigate the expression pattern of S100P in the human PLACENTA during PREGNANCY development.Materials and Methods: In this experimental study, we collected 16 first-trimester PLACENTAl tissues, 10 second-trimester PLACENTAl tissues, and 12 term PLACENTAs. The mRNA expression levels of S100P were detected by reverse-transcription-polymerase chain reaction (RT-PCR) and quantitative real-time PCR, the protein expression levels were detected by western blot, and the localization of S100P was measured by immunohistochemical staining. The values obtained from PCR and western blot analysis were expressed as the mean±SD. Levene’s test was used to test equal variances, and one-way analysis of variance (ANOVA) was used to evaluate differences between groups.Results: Protein and mRNA expression of S100P could be detected in PLACENTA during PREGNANCY, with minor higher levels in first-trimester (p>0.05). Immunohistochemical staining revealed that S100P protein was strongly expressed in syncytiotrophoblasts, and moderate expression was detected in villous cytotrophoblasts and cytotrophoblast columns. The S100P protein was localized to both cytoplasm and nuclei in syncytiotrophoblasts, while it only existed in the cytoplasm of cytotrophoblasts.Conclusion: S100P was strongly detected in human PLACENTA during PREGNANCY. The specific expression and distribution of S100P in human PLACENTA throughout gestation suggested that S100P function might vary with its location in the PLACENTA.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    ZHU, HAI YAN, TONG, XIAO MEI, LIN, XIAO NA, JIANG, LING YING, WANG, JUN XIA, & ZHANG, SONG YING. (2015). EXPRESSION AND DISTRIBUTION OF CALCIUM-BINDING PROTEIN S100P IN HUMAN PLACENTA DURING PREGNANCY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 8(4), 445-452. SID. https://sid.ir/paper/305781/en

    Vancouver: Copy

    ZHU HAI YAN, TONG XIAO MEI, LIN XIAO NA, JIANG LING YING, WANG JUN XIA, ZHANG SONG YING. EXPRESSION AND DISTRIBUTION OF CALCIUM-BINDING PROTEIN S100P IN HUMAN PLACENTA DURING PREGNANCY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2015;8(4):445-452. Available from: https://sid.ir/paper/305781/en

    IEEE: Copy

    HAI YAN ZHU, XIAO MEI TONG, XIAO NA LIN, LING YING JIANG, JUN XIA WANG, and SONG YING ZHANG, “EXPRESSION AND DISTRIBUTION OF CALCIUM-BINDING PROTEIN S100P IN HUMAN PLACENTA DURING PREGNANCY,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 8, no. 4, pp. 445–452, 2015, [Online]. Available: https://sid.ir/paper/305781/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button