COMPARISON BETWEEN UNILATERAL AND BILATERAL OVARIAN DRILLING IN CLOMIPHENE CITRATE RESISTANCE POLYCYSTIC OVARY SYNDROME PATIENTS: A RANDOMIZED CLINICAL TRIAL OF EFFICACY

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ZAHIRI SOROURI ZIBA; SHARAMI SEYEDEH HAJAR; TAHERSIMA ZINAB; SALAMAT FATEMEH

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Journal Paper

Paper Information

Journal: International Journal of Fertility & Sterility Year:2015 | Volume:9 | Issue:1 Page(s): 9-16

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Title

COMPARISON BETWEEN UNILATERAL AND BILATERAL OVARIAN DRILLING IN CLOMIPHENE CITRATE RESISTANCE POLYCYSTIC OVARY SYNDROME PATIENTS: A RANDOMIZED CLINICAL TRIAL OF EFFICACY

Author(s)

ZAHIRI SOROURI ZIBA | SHARAMI SEYEDEH HAJAR | TAHERSIMA ZINAB | SALAMAT FATEMEH | Issue Writer Certificate

Keywords

BILATERAL

UNILATERAL

OVARIAN INDUCTION

POLYCYSTIC OVARY SYNDROME

Abstract

Background: Laparoscopic ovarian drilling (LOD) is an alternative method to induce ovulation in POLYCYSTIC OVARY SYNDROME (PCOS) patients with clomiphene citrate (CC) resistant instead of gonadotropins. This study aimed to compare the efficacy of UNILATERAL LOD (ULOD) versus BILATERAL LOD (BLOD) in CC resistance PCOS patients in terms of ovulation and pregnancy rates.Materials and Methods: In a prospective randomized clinical trial study, we included 100 PCOS patients with CC resistance attending to Al-Zahra Hospital in Rasht, Guilan Province, Iran, from June 2011 to July 2012. Patients were randomly divided into two ULOD and BLOD groups with equal numbers. The clinical and biochemical responses on ovulation and pregnancy rates were assessed over a 6-month follow-up period.Results: Differences in baseline characteristics of patients between two groups prior to laparoscopy were not significant (p>0.05). There were no significant differences between the two groups in terms of clinical and biochemical responses, spontaneous menstruation (66.1 vs.71.1%), spontaneous ovulation rate (60 vs.64.4%), and pregnancy rate (33.1 vs.40%) (p>0.05). Following drilling, there was a significant decrease in mean serum concentrations of luteinizing hormone (LH) (p=0.001) and testosterone (p=0.001) in both the groups. Mean decrease in serum LH (p=0.322) and testosterone concentrations (p=0.079) were not statistically significant between two groups. Mean serum level of follicle stimulating hormone (FSH) did not change significantly in two groups after LOD (p>0.05).Conclusion: Based on results of this study, ULOD seems to be equally efficacious as BLOD in terms of ovulation and pregnancy rates (Registration Number: IRCT138903291306N2).

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References

LAPAROSCOPIC OVARIAN DRILLING IN CLOMIPHENE RESISTANT PCO PATIENTS: A PREFERRED METHOD OF TREATMENT

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APA: Copy

ZAHIRI SOROURI, ZIBA, SHARAMI, SEYEDEH HAJAR, TAHERSIMA, ZINAB, & SALAMAT, FATEMEH. (2015). COMPARISON BETWEEN UNILATERAL AND BILATERAL OVARIAN DRILLING IN CLOMIPHENE CITRATE RESISTANCE POLYCYSTIC OVARY SYNDROME PATIENTS: A RANDOMIZED CLINICAL TRIAL OF EFFICACY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 9(1), 9-16. SID. https://sid.ir/paper/305795/en

Vancouver: Copy

ZAHIRI SOROURI ZIBA, SHARAMI SEYEDEH HAJAR, TAHERSIMA ZINAB, SALAMAT FATEMEH. COMPARISON BETWEEN UNILATERAL AND BILATERAL OVARIAN DRILLING IN CLOMIPHENE CITRATE RESISTANCE POLYCYSTIC OVARY SYNDROME PATIENTS: A RANDOMIZED CLINICAL TRIAL OF EFFICACY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2015;9(1):9-16. Available from: https://sid.ir/paper/305795/en

IEEE: Copy

ZIBA ZAHIRI SOROURI, SEYEDEH HAJAR SHARAMI, ZINAB TAHERSIMA, and FATEMEH SALAMAT, “COMPARISON BETWEEN UNILATERAL AND BILATERAL OVARIAN DRILLING IN CLOMIPHENE CITRATE RESISTANCE POLYCYSTIC OVARY SYNDROME PATIENTS: A RANDOMIZED CLINICAL TRIAL OF EFFICACY,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 9, no. 1, pp. 9–16, 2015, [Online]. Available: https://sid.ir/paper/305795/en

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