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Information Journal Paper

Title

A PRELIMINARY REPORT OF A LOW-DOSE STEP-UP REGIMEN OF RECOMBINANT HUMAN FSH FOR YOUNG WOMEN UNDERGOING OVULATION INDUCTION WITH IUI

Pages

  436-441

Abstract

 Background: The aim of this study was to evaluate the efficacy and safety of a recombinant human follicle stimulating hormone (r-FSH) low-dose step-up regimen for controlled ovarian hyperstimulation in patients undergoing OVULATION INDUCTION (OI) with intrauterine insemination (IUI).Materials and Methods: The study was conducted in the Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei, Taiwan. In this prospective, observational study, consecutive infertile women (20-35 years) with regular menstrual cycles and a normal baseline FSH level were prospectively enrolled between January 2010 and September 2010. A starting dose of 112.5 IU/day r-FSH was administered on day 3 and increased by 37.5 IU/day every 2 days until a follicle³11 mm in diameter was present. Recombinant human chorionic gonadotropin (r-hCG) was administered when a follicle³18 mm was noted. Monifollicular development was defined as only one follicle with a diameter³16 mm. Clinical pregnancy was defined as a pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs.Results: A total of 29 women and 30 cycles were included. The mean daily dose of r-FSH to achieve a follicle of³11 mm in diameter was 131.3±23.6 IU and the mean total dose was 1030.0±383.2 IU. Approximately 41% of the cycles were monofollicular. Clinical pregnancy was observed in 9 (30.0%) cycles, and a fetal heart beat was observed in 7 (23.3%). There were no multiple pregnancies. Mild OVARIAN HYPERSTIMULATION SYNDROME, which was resolved with conservative management, was observed in 3 (10.0%) cycles.Conclusion: This r-FSH low-dose step-up regimen seems to be a feasible and practical method for OI in younger infertile women undergoing IUI.

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    APA: Copy

    LU, HSIN FEN, PENG, FU SHIANG, CHEN, SHEE UAN, CHIU, BAO CHU, YEH, SZU HSING, & HSIAO, SHENG MOU. (2016). A PRELIMINARY REPORT OF A LOW-DOSE STEP-UP REGIMEN OF RECOMBINANT HUMAN FSH FOR YOUNG WOMEN UNDERGOING OVULATION INDUCTION WITH IUI. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 9(4), 436-441. SID. https://sid.ir/paper/305841/en

    Vancouver: Copy

    LU HSIN FEN, PENG FU SHIANG, CHEN SHEE UAN, CHIU BAO CHU, YEH SZU HSING, HSIAO SHENG MOU. A PRELIMINARY REPORT OF A LOW-DOSE STEP-UP REGIMEN OF RECOMBINANT HUMAN FSH FOR YOUNG WOMEN UNDERGOING OVULATION INDUCTION WITH IUI. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2016;9(4):436-441. Available from: https://sid.ir/paper/305841/en

    IEEE: Copy

    HSIN FEN LU, FU SHIANG PENG, SHEE UAN CHEN, BAO CHU CHIU, SZU HSING YEH, and SHENG MOU HSIAO, “A PRELIMINARY REPORT OF A LOW-DOSE STEP-UP REGIMEN OF RECOMBINANT HUMAN FSH FOR YOUNG WOMEN UNDERGOING OVULATION INDUCTION WITH IUI,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 9, no. 4, pp. 436–441, 2016, [Online]. Available: https://sid.ir/paper/305841/en

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