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Information Journal Paper

Title

PRENATAL CAFFEINE EXPOSURE IMPAIRS PREGNANCY IN RATS

Pages

  558-562

Keywords

RAT 

Abstract

 Background: In recent years, concerns have been raised about human reproductive disorders. CAFFEINE consumption is increasing by the world’s population and there is a relationship between CAFFEINE intake and adverse reproductive outcomes. The aim of this study was to evaluate the effects of CAFFEINE on IMPLANTATION sites, number of live births, birth weight, crown-rump length (CRL) and abnormality in pregnant RATs.Materials and Methods: In this experimental study, 40 female albino RATs (170-190 g) were randomly divided into two experimental and two control groups (n=10/each group). In both experimental groups, animals received CAFFEINE intraperitoneally (IP: 150 mg/kg/day) on days 1-5 of pregnancy. In experimental group 1, treated animals were euthanized on day 7of pregnancy and the number of IMPLANTATION sites was counted. In experimental group 2, treated animals maintained pregnant and after delivery, the number of live births, birth weight, CRL and abnormality of neonates were investigated. In control group, animals received IP injections of distilled water. Data were analyzed by independent t test.Results: Results showed that administration of CAFFEINE significantly decreased the number of IMPLANTATION sites, number of live births and CRL as compared with control group (P<0.05). There were no significant differences regarding birth weight and abnormality of neonate RATs between experimental and control groups.Conclusion: These results suggest that CAFFEINE caused anti-fertility effect and significantly decreased CRL in neonate RATs.

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    Cite

    APA: Copy

    YADEGARI, MARYAM, KHAZAEI, MOZAFAR, ANVARI, MORTEZA, & ESKANDARI, MOHADESEH. (2016). PRENATAL CAFFEINE EXPOSURE IMPAIRS PREGNANCY IN RATS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 9(4), 558-562. SID. https://sid.ir/paper/305853/en

    Vancouver: Copy

    YADEGARI MARYAM, KHAZAEI MOZAFAR, ANVARI MORTEZA, ESKANDARI MOHADESEH. PRENATAL CAFFEINE EXPOSURE IMPAIRS PREGNANCY IN RATS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2016;9(4):558-562. Available from: https://sid.ir/paper/305853/en

    IEEE: Copy

    MARYAM YADEGARI, MOZAFAR KHAZAEI, MORTEZA ANVARI, and MOHADESEH ESKANDARI, “PRENATAL CAFFEINE EXPOSURE IMPAIRS PREGNANCY IN RATS,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 9, no. 4, pp. 558–562, 2016, [Online]. Available: https://sid.ir/paper/305853/en

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