THYROXIN IS USEFUL TO IMPROVE SPERM MOTILITY

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MENDELUK GABRIELA RUTH; ROSALES MONICA

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Journal Paper

Paper Information

Journal: International Journal of Fertility & Sterility Year:2016 | Volume:10 | Issue:2 Page(s): 208-214

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Information Journal Paper

Title

THYROXIN IS USEFUL TO IMPROVE SPERM MOTILITY

Author(s)

MENDELUK GABRIELA RUTH | ROSALES MONICA | Issue Writer Certificate

Keywords

SPERM MOTILITY

THYROXIN

PENTOXIFYLLINE

ARTIFICIAL INSEMINATION

Abstract

Background: The aim of this study was to evaluate the non-genomic action of THYROXIN on sperm kinetic and its probable use to improve sperm recovery after applying an enrichment method like "swim-up" in comparison with the available one, PENTOXIFYLLINE.Materials and Methods: This is an experimental study. A total of 50 patients were recruited, followed by infertility consultation. Conventional sperm assays were performed according to World Health Organization criteria-2010 (WHO-2010). A Computer Aided Semen Analysis System was employed to assess kinetic parameters and concentrations. Number of the motile sperm recovered after preparation technique was calculated.Results: Addition of T4 (0.002 mg/ml) to semen samples increased hypermotility at 20 minutes (control: 14.18±5.1% vs.17.66±8.88%, P<0.03, data expressed as mean±SD) and remained unchanged after 40 minutes. Significant differences were found in the motile sperm recovered after swim-up (control: 8.93×106±9.52×06 vs.17.20×106±21.16×106, P<0.03), achieving all of the tested samples a desirable threshold value for ARTIFICIAL INSEMINATION outcome, while adding PENTOXIFYLLINE increased the number of recovered sperm after swim-up in 60% of the studied cases. No synergism between two treatments could be determined.Conclusion: We propose a new physiological tool to artificially improve insemination. The discussion opens windows to investigate unknown pathways involved in sperm capacitation and gives innovative arguments to better understand infertility mechanisms.

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APA: Copy

MENDELUK, GABRIELA RUTH, & ROSALES, MONICA. (2016). THYROXIN IS USEFUL TO IMPROVE SPERM MOTILITY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 10(2), 208-214. SID. https://sid.ir/paper/305885/en

Vancouver: Copy

MENDELUK GABRIELA RUTH, ROSALES MONICA. THYROXIN IS USEFUL TO IMPROVE SPERM MOTILITY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2016;10(2):208-214. Available from: https://sid.ir/paper/305885/en

IEEE: Copy

GABRIELA RUTH MENDELUK, and MONICA ROSALES, “THYROXIN IS USEFUL TO IMPROVE SPERM MOTILITY,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 10, no. 2, pp. 208–214, 2016, [Online]. Available: https://sid.ir/paper/305885/en

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