مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

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Information Journal Paper

Title

GENE POLYMORPHISM OF MATRIX METALLOPROTEINASE 9 IN ASTHENOZOOSPERMIC MALE SUBJECTS

Pages

  247-252

Abstract

 Background: MATRIX METALLOPROTEINASE (MMPs) play important roles in the structural and functional properties of reproductive organs. The aim of this study is to determine the prevalence of C-1562T MMP-9 (rs3918242) gene POLYMORPHISM in fertile and infertile men. In addition, we aim to determine the association between C-1562T MMP-9 and G-1575A MMP-2 gene POLYMORPHISMs.Materials and Methods: A total of 400 subjects, including 200 fertile and 200 infertile men, were recruited for this case-control study. The allele frequencies and genotype distributions of SINGLE NUCLEOTIDE POLYMORPHISM in the promoter regions of MMP-9 (C-1562T) were determined using polymerase chain reaction-restriction fragment length POLYMORPHISM (PCR-RFLP) analysis. The chi-square (c2) test was used to assess the distribution of genotype frequencies.Results: There were no significant differences found in the genotype distributions or allele frequencies between fertile and infertile men for the C-1562T MMP-9 gene POLYMORPHISM. The percent of immotile sperm in infertile men with the CC and CT genotypes of C-1562T MMP-9 gene POLYMORPHISM significantly differed compared with that of subjects with the TT genotype. The frequency of CC/GA-combined genotypes of C-1562T MMP-9 and G-1575A MMP-2 gene POLYMORPHISMs significantly differed in fertile and infertile men (P=0.031).Conclusion: Our results suggest that genetic POLYMORPHISMs in MMP may impact male fertility.

Cites

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    • Cite

    APA: Copy

    MOHAGHEGHI, SINA, KHODADADI, IRAJ, KARAMI, MANOOCHEHR, AMIRI, IRAJ, & TAVILANI, HEIDAR. (2018). GENE POLYMORPHISM OF MATRIX METALLOPROTEINASE 9 IN ASTHENOZOOSPERMIC MALE SUBJECTS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 11(4), 247-252. SID. https://sid.ir/paper/305954/en

    Vancouver: Copy

    MOHAGHEGHI SINA, KHODADADI IRAJ, KARAMI MANOOCHEHR, AMIRI IRAJ, TAVILANI HEIDAR. GENE POLYMORPHISM OF MATRIX METALLOPROTEINASE 9 IN ASTHENOZOOSPERMIC MALE SUBJECTS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2018;11(4):247-252. Available from: https://sid.ir/paper/305954/en

    IEEE: Copy

    SINA MOHAGHEGHI, IRAJ KHODADADI, MANOOCHEHR KARAMI, IRAJ AMIRI, and HEIDAR TAVILANI, “GENE POLYMORPHISM OF MATRIX METALLOPROTEINASE 9 IN ASTHENOZOOSPERMIC MALE SUBJECTS,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 11, no. 4, pp. 247–252, 2018, [Online]. Available: https://sid.ir/paper/305954/en

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