THE ASSOCIATION OF PPARγ PRO12ALA AND C161T POLYMORPHISMS WITH POLYCYSTIC OVARY SYNDROME AND THEIR INFLUENCE ON LIPID AND LIPOPROTEIN PROFILES

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RAHIMI ZOHREH; CHAMAIE NEJAD FOROOGH; SAEIDI SHOHREH; RAHIMI ZIBA; EBRAHIMI ALI; SHAKIBA EBRAHIM; VAISI RAYGANI ASAD

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Journal: International Journal of Fertility & Sterility Year:2018 | Volume:12 | Issue:2 Page(s): 147-151

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Title

THE ASSOCIATION OF PPARγ PRO12ALA AND C161T POLYMORPHISMS WITH POLYCYSTIC OVARY SYNDROME AND THEIR INFLUENCE ON LIPID AND LIPOPROTEIN PROFILES

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Keywords

ESTRADIOL

LIPID

LIPOPROTEIN

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR

POLYCYSTIC OVARY SYNDROME

Abstract

Background: The aim of present study was to clarify the role of the PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) g Pro12Ala and C161T polymorphisms in the pathogenesis of POLYCYSTIC OVARY SYNDROME (PCOS) and their influence on LIPID and LIPOPROTEIN profiles of patients.Materials and Methods: The present cross-sectional study consisted of 50 women with PCOS, who referred to the Kermanshah University of Medical Sciences Clinic between April and October 2015, and 233 unrelated age-matched healthy women from the same region (West Iran). The PPARg Pro12Ala and PPARg C161T polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. Fasting blood sugar (FBS), serum triglycerides (TG), cholesterol, low density LIPOPROTEIN- cholesterol (LDL-C), high density LIPOPROTEIN-cholesterol (HDL-C) and ESTRADIOL levels were measured.Results: The serum level of ESTRADIOL was significantly lower in PCOS patients compared to healthy women. The PPARg Pro12Ala (CG) genotype increased the risk of PCOS 2.96-fold. The frequency of the PPARg T allele (at C161T) was 21% in patients and 17.2% in controls with no significant difference (P=0.52). In all studied individuals, the PPARg CG genotype was associated with significantly higher levels of TG. However, significantly lower levels of total cholesterol and LDL-C were observed in PPARg TT individuals compared with those with the CC genotype. Within the PCOS group, the PPARg CG genotype was significantly associated with lower levels of ESTRADIOL compared with the CC genotype. Also, the CG genotype was significantly associated with higher levels of TG when compared with the CC genotype.Conclusion: Our study shows that, unlike PPARg C161T, PPARg Pro12Ala is associated with the risk of PCOS. Also, we found that the LIPID and LIPOPROTEIN profiles significantly vary based on PPARg Pro12Ala and C161T genotypes.

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APA: Copy

RAHIMI, ZOHREH, CHAMAIE NEJAD, FOROOGH, SAEIDI, SHOHREH, RAHIMI, ZIBA, EBRAHIMI, ALI, SHAKIBA, EBRAHIM, & VAISI RAYGANI, ASAD. (2018). THE ASSOCIATION OF PPARγ PRO12ALA AND C161T POLYMORPHISMS WITH POLYCYSTIC OVARY SYNDROME AND THEIR INFLUENCE ON LIPID AND LIPOPROTEIN PROFILES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 12(2), 147-151. SID. https://sid.ir/paper/305980/en

Vancouver: Copy

RAHIMI ZOHREH, CHAMAIE NEJAD FOROOGH, SAEIDI SHOHREH, RAHIMI ZIBA, EBRAHIMI ALI, SHAKIBA EBRAHIM, VAISI RAYGANI ASAD. THE ASSOCIATION OF PPARγ PRO12ALA AND C161T POLYMORPHISMS WITH POLYCYSTIC OVARY SYNDROME AND THEIR INFLUENCE ON LIPID AND LIPOPROTEIN PROFILES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2018;12(2):147-151. Available from: https://sid.ir/paper/305980/en

IEEE: Copy

ZOHREH RAHIMI, FOROOGH CHAMAIE NEJAD, SHOHREH SAEIDI, ZIBA RAHIMI, ALI EBRAHIMI, EBRAHIM SHAKIBA, and ASAD VAISI RAYGANI, “THE ASSOCIATION OF PPARγ PRO12ALA AND C161T POLYMORPHISMS WITH POLYCYSTIC OVARY SYNDROME AND THEIR INFLUENCE ON LIPID AND LIPOPROTEIN PROFILES,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 12, no. 2, pp. 147–151, 2018, [Online]. Available: https://sid.ir/paper/305980/en

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