IL-1α C376A TRANSVERSION VARIANT AND RISK OF IDIOPATHIC MALE INFERTILITY IN IRANIAN MEN: A GENETIC ASSOCIATION STUDY

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ZAMANI BADI TAYYEBEH; KARIMIAN MOHAMMAD; AZAMI TAMEH ABOLFAZL; NIKZAD HOSSEIN

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Journal: International Journal of Fertility & Sterility Year:2018 | Volume:12 | Issue:3 Page(s): 229-234

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Title

IL-1α C376A TRANSVERSION VARIANT AND RISK OF IDIOPATHIC MALE INFERTILITY IN IRANIAN MEN: A GENETIC ASSOCIATION STUDY

Author(s)

ZAMANI BADI TAYYEBEH | KARIMIAN MOHAMMAD | AZAMI TAMEH ABOLFAZL | NIKZAD HOSSEIN | Issue Writer Certificate

Keywords

GENETIC POLYMORPHISM

INTERLEUKIN-1α

MALE INFERTILITY

SPERMATOGENESIS

Abstract

Background: IL-1a produced by Sertoli cells is considered to act as a growth factor for spermatogonia. In this study, we investigated the association of the C376A polymorphism in IL-1a with MALE INFERTILITY in men referring to the Kashan IVF Center.Materials and Methods: In this case-control study, 2 ml of blood was collected from 230 fertile and 230 infertile men. After DNA extraction, the C376A variant was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In addition, the molecular effects of the C376A transversion were analysed using bioinformatics tools.Results: A significant association was observed between the homozygous genotype CC with MALE INFERTILITY [odds ratio (OR)=1.97, 95% confidence interval (CI)=1.14-3.41, P=0.016)]. Carriers of C (AC+CC) showed a similar risk for MALE INFERTILITY (OR=1.78, 95% CI=1.06-2.99, P=0.030). Also, allelic analysis showed that the C allele is associated with MALE INFERTILITY (OR=1.43, 95% CI=1.09-1.88, P=0.011). In sub-group analysis, we found that the AC genotype is associated with asthenozoospermia (OR=2.38, 95% CI=1.03-5.53, P=0.043). In addition, carriers of C were at high risk for asthenozoospermia (OR=2.25, 95% CI=1.01-4.10, P=0.047). Also, C allele was significantly associated with oligozoospermia (OR=1.44, 95% CI=1.01-2.06, P=0.049) and non-obstructive azoospermia (OR=1.67, 95% CI =1.04-2.68, P=0.034). Finally, in silico analysis showed that the C376A polymorphism could alter splicing especially in the acceptor site.Conclusion: This is the preliminary report on the association of IL-1a C376A polymorphism with MALE INFERTILITY in the Kashan population. This association shows that theIL-1α gene may be a biomarker for MALE INFERTILITY, and therefore needs additional investigations in future studies to validate this.

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APA: Copy

ZAMANI BADI, TAYYEBEH, KARIMIAN, MOHAMMAD, AZAMI TAMEH, ABOLFAZL, & NIKZAD, HOSSEIN. (2018). IL-1α C376A TRANSVERSION VARIANT AND RISK OF IDIOPATHIC MALE INFERTILITY IN IRANIAN MEN: A GENETIC ASSOCIATION STUDY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 12(3), 229-234. SID. https://sid.ir/paper/305997/en

Vancouver: Copy

ZAMANI BADI TAYYEBEH, KARIMIAN MOHAMMAD, AZAMI TAMEH ABOLFAZL, NIKZAD HOSSEIN. IL-1α C376A TRANSVERSION VARIANT AND RISK OF IDIOPATHIC MALE INFERTILITY IN IRANIAN MEN: A GENETIC ASSOCIATION STUDY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2018;12(3):229-234. Available from: https://sid.ir/paper/305997/en

IEEE: Copy

TAYYEBEH ZAMANI BADI, MOHAMMAD KARIMIAN, ABOLFAZL AZAMI TAMEH, and HOSSEIN NIKZAD, “IL-1α C376A TRANSVERSION VARIANT AND RISK OF IDIOPATHIC MALE INFERTILITY IN IRANIAN MEN: A GENETIC ASSOCIATION STUDY,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 12, no. 3, pp. 229–234, 2018, [Online]. Available: https://sid.ir/paper/305997/en

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