ASSOCIATION OF TUMOR NECROSIS FACTOR-α (TNF-α) -308G>A AND -238G>A POLYMORPHISMS WITH RECURRENT PREGNANCY LOSS RISK: A META-ANALYSIS

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ASLEBAHAR FERESHTEH; NEAMATZADEH HOSSEIN; MEIBODI BAHARE; KARIMI ZARCHI MOJGAN; TABATABAEI RAZIEH SADAT; NOORI SHADKAM MAHMOOD; MAZAHERI MAHTA; DEHGHANI MOHAMMADABADI REIHANEH

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Journal: International Journal of Fertility & Sterility Year:2019 | Volume:12 | Issue:4 Page(s): 284-292

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Title

ASSOCIATION OF TUMOR NECROSIS FACTOR-α (TNF-α) -308G>A AND -238G>A POLYMORPHISMS WITH RECURRENT PREGNANCY LOSS RISK: A META-ANALYSIS

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Keywords

META-ANALYSIS

MISCARRIAGE

PREGNANCY LOSS

POLYMORPHISM

TUMOR NECROSIS FACTOR-α

Abstract

Background: Multiple studies have been carried out examining the association of tumor necrosis factor-α gene (TNF- a) promoter region POLYMORPHISMs with recurrent PREGNANCY LOSS (RPL) risk. However, the results remain controversial and incomplete. Hence, we performed a META-ANALYSIS to evaluate the association of the TNF- a -308G>A and -238G>A POLYMORPHISMs with RPL risk.Materials and Methods: In this META-ANALYSIS, a comprehensive search of PubMed, Web of Knowledge and EMBASE was performed to identify relevant studies published until December 1, 2017. The associations were assessed by odds ratio (OR) and its corresponding 95% confidence interval (CI).Results: A total of 29 case-control studies, comprising 20 studies on TNF- a -308G>A (3,461 cases and 3,895 controls) and nine studies on TNF- a -238G>A (2,589 cases and 2,664 controls), were included in the META-ANALYSIS. Overall, we found TNF-α -308G>A to be associated with an increase in RPL risk under the homozygote (OR=1.716, 95% CI: 1.210-2.433, P=0.002) and the recessive (OR=1.554, 95% CI: 1.100-2.196, P=0.012) models. TNF- a -238G>A was also significantly associated with increased risk of RPL under the allele model (OR=1.554, 95% CI: 1.100-2.196, P=0.012). Stratified analysis revealed a more significant association between the TNF- a -308G>A POLYMORPHISM and increased RPL risk in Asians under the homozygote (OR=2.190, 95% CI: 1.465-3.274, P≤0.001), the dominant (OR=1.642, 95% CI: 1.269-2.125, P≤0.001) and the recessive (OR=1.456, 95% CI: 1.039-2.040, P=0.029) models, but not in Caucasians. A non-significant association was, however, identified between TNF- a -238G>A and RPL risk based on ethnicity. Moreover, TNF- a -308G>A and -238G>A POLYMORPHISMs were significantly associated with increased risk of RPL in high quality studies and polymerase chain reaction-restriction fragment length POLYMORPHISM (PCR-RFLP) subgroups.Conclusion: The present META-ANALYSIS demonstrates that TNF-a -308G>A and -238G>A POLYMORPHISMs are associated with an increased risk of RPL.

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APA: Copy

ASLEBAHAR, FERESHTEH, NEAMATZADEH, HOSSEIN, MEIBODI, BAHARE, KARIMI ZARCHI, MOJGAN, TABATABAEI, RAZIEH SADAT, NOORI SHADKAM, MAHMOOD, MAZAHERI, MAHTA, & DEHGHANI MOHAMMADABADI, REIHANEH. (2019). ASSOCIATION OF TUMOR NECROSIS FACTOR-α (TNF-α) -308G>A AND -238G>A POLYMORPHISMS WITH RECURRENT PREGNANCY LOSS RISK: A META-ANALYSIS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 12(4), 284-292. SID. https://sid.ir/paper/306008/en

Vancouver: Copy

ASLEBAHAR FERESHTEH, NEAMATZADEH HOSSEIN, MEIBODI BAHARE, KARIMI ZARCHI MOJGAN, TABATABAEI RAZIEH SADAT, NOORI SHADKAM MAHMOOD, MAZAHERI MAHTA, DEHGHANI MOHAMMADABADI REIHANEH. ASSOCIATION OF TUMOR NECROSIS FACTOR-α (TNF-α) -308G>A AND -238G>A POLYMORPHISMS WITH RECURRENT PREGNANCY LOSS RISK: A META-ANALYSIS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2019;12(4):284-292. Available from: https://sid.ir/paper/306008/en

IEEE: Copy

FERESHTEH ASLEBAHAR, HOSSEIN NEAMATZADEH, BAHARE MEIBODI, MOJGAN KARIMI ZARCHI, RAZIEH SADAT TABATABAEI, MAHMOOD NOORI SHADKAM, MAHTA MAZAHERI, and REIHANEH DEHGHANI MOHAMMADABADI, “ASSOCIATION OF TUMOR NECROSIS FACTOR-α (TNF-α) -308G>A AND -238G>A POLYMORPHISMS WITH RECURRENT PREGNANCY LOSS RISK: A META-ANALYSIS,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 12, no. 4, pp. 284–292, 2019, [Online]. Available: https://sid.ir/paper/306008/en

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