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Information Journal Paper

Title

COMPARING THE EFFECTS OF GLYCYRRHIZA GLABRA ROOT EXTRACT, A CYCLOOXYGENASE-2 INHIBITOR (CELECOXIB) AND AGONADOTROPIN-RELEASING HORMONE ANALOG (DIPHERELINE) INA RAT MODEL OF ENDOMETRIOSIS

Pages

  45-50

Abstract

 Background: The purpose of this study was to compare the effects of GLYCYRRHIZA GLABRA (Licorice), a CYCLOOXYGENASE-2 INHIBITOR (CELECOXIB) and a gonadotropin-releasing hormone analog (Diphereline® ), with a control group onendometrial implants in rats. Materials and Methods: In this experimental study, ENDOMETRIOSIS was induced in rats by auto transplantation andafter confirmation, the rats were divided into 4 groups that were treated for 6 weeks with normal saline (0. 5 ml/day, orally), licorice extract (3000 mg/kg/day, orally), CELECOXIB (50 mg/kg, twice a day, orally) or diphereline (3 mg/kg, intramuscularly). At the end of treatments, the mean area, volume, histopathology and hemosiderin-laden macrophage(HLM) counts of the endometrial implants were evaluated and compared among the four groups. Results: The mean area, volume and HLM counts of the implants in the licorice group were significantly lower thanthose of the control group (P<0. 001). The histopathologic grades of endometrial implants were significantly decreasedby licorice compared to the control group (P<0. 001). There was no significant change in the mentioned parameters inrats treated with CELECOXIB compared to the control group. Diphereline was the most potent agent for suppressing thegrowth of endometrial implants in terms of all of the above-mentioned parameters. Conclusion: Licorice decreased the growth and histopathologic grades of auto-transplanted endometrial implants. However, while celcoxib had no significant effect, diphereline showed the highest potency for decreasing the endometrialgrowth. Licorice may have the potential to be used as an alternative medication for the treatment of ENDOMETRIOSIS.

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    APA: Copy

    NAMAVAR JAHROMI, BAHIA, FARROKHNIA, FARNAZ, TANIDEH, NADER, VIJAYANANDA KUMAR, PERIKALA, PARSANEZHAD, MOHAMMAD EBRAHIM, & ALAEE, SANAZ. (2019). COMPARING THE EFFECTS OF GLYCYRRHIZA GLABRA ROOT EXTRACT, A CYCLOOXYGENASE-2 INHIBITOR (CELECOXIB) AND AGONADOTROPIN-RELEASING HORMONE ANALOG (DIPHERELINE) INA RAT MODEL OF ENDOMETRIOSIS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 13(1), 45-50. SID. https://sid.ir/paper/306022/en

    Vancouver: Copy

    NAMAVAR JAHROMI BAHIA, FARROKHNIA FARNAZ, TANIDEH NADER, VIJAYANANDA KUMAR PERIKALA, PARSANEZHAD MOHAMMAD EBRAHIM, ALAEE SANAZ. COMPARING THE EFFECTS OF GLYCYRRHIZA GLABRA ROOT EXTRACT, A CYCLOOXYGENASE-2 INHIBITOR (CELECOXIB) AND AGONADOTROPIN-RELEASING HORMONE ANALOG (DIPHERELINE) INA RAT MODEL OF ENDOMETRIOSIS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2019;13(1):45-50. Available from: https://sid.ir/paper/306022/en

    IEEE: Copy

    BAHIA NAMAVAR JAHROMI, FARNAZ FARROKHNIA, NADER TANIDEH, PERIKALA VIJAYANANDA KUMAR, MOHAMMAD EBRAHIM PARSANEZHAD, and SANAZ ALAEE, “COMPARING THE EFFECTS OF GLYCYRRHIZA GLABRA ROOT EXTRACT, A CYCLOOXYGENASE-2 INHIBITOR (CELECOXIB) AND AGONADOTROPIN-RELEASING HORMONE ANALOG (DIPHERELINE) INA RAT MODEL OF ENDOMETRIOSIS,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 13, no. 1, pp. 45–50, 2019, [Online]. Available: https://sid.ir/paper/306022/en

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