ANALYSIS OF PRM1 AND PRM2 POLYMORPHISMS IN IRANIAN INFERTILE MEN WITH IDIOPATHIC TERATOZOOSPERMIA, SHORT COMMUNICATION

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DEHGHANPOUR FATEMEH; FESAHAT FARZANEH; MIRESMAEILI SEYED MOHSEN; ZARE MEHRJARDI EHSAN; HONARJU AHMAD; TALEBI ALI REZA

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Journal: International Journal of Fertility & Sterility Year:2019 | Volume:13 | Issue:1 Page(s): 77-82

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Title

ANALYSIS OF PRM1 AND PRM2 POLYMORPHISMS IN IRANIAN INFERTILE MEN WITH IDIOPATHIC TERATOZOOSPERMIA, SHORT COMMUNICATION

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Keywords

SINGLE NUCLEOTIDE POLYMORPHISMS

SPERM

TERATOZOOSPERMIA

Abstract

SINGLE NUCLEOTIDE POLYMORPHISMS (SNPs) in a number of genes involved in SPERM maturation are considered as one ofthe main factors for male infertility. The aim of the present case-control study was to examine the association of SNPsin protamine1 (PRM1) and protamine2 (PRM2) genes with idiopathic TERATOZOOSPERMIA. In this case-control study, some SNPs in PRM1 (c. 49 C>T, c. 102 G>T and c. 230A>C) and PRM2 (rs545828790, rs115686767, rs201933708, rs2070923 and rs1646022) were investigated in 30 idiopathic infertile men with TERATOZOOSPERMIA (case group) incomparison with 35 fertile men (controls). Genotyping of SNPs was undertaken using polymerase chain reaction(PCR)-direct sequencing. For PRM1, c. 230A>C, as a synonymous polymorphism, was detected in both teratozoospermicmen (heterozygous n=26, homozygous minor n=1) allele frequency C(48) A(52) and controls (heterozygousn=15, homozygous minor n=4). All cases and controls were genotyped for rs545828790 in PRM2, a missense polymorphism, as well as rs115686767 and rs201933708, both of which synonymous variants. The findings showed anintronic variant in PRM2 (rs2070923) was also present in both groups. Also, rs1646022, a missense polymorphism, occurred in teratozoospermic men (heterozygous n=10, homozygous minor n=5) and controls (heterozygous n=13, homozygous minor n=2). However, there were no significant differences in SNPs of PRM1 and PRM2 between thetwo groups, however, for c. 230A>C, the frequency of the CA genotype was significantly higher in infertile men withteratozoospermia (P=0. 001). We demonstrate that PRM2 G398C and A473C polymorphisms were associated with theteratozoospermia and its genetic variation was in relation to semen quality, SPERM apoptosis, and morphology in theIranian population. This study is a preliminary study and presenting data as part of a future comprehensive study toclinically establish whether these gene polymorphisms are biomarkers for susceptibility to TERATOZOOSPERMIA.

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APA: Copy

DEHGHANPOUR, FATEMEH, FESAHAT, FARZANEH, MIRESMAEILI, SEYED MOHSEN, ZARE MEHRJARDI, EHSAN, HONARJU, AHMAD, & TALEBI, ALI REZA. (2019). ANALYSIS OF PRM1 AND PRM2 POLYMORPHISMS IN IRANIAN INFERTILE MEN WITH IDIOPATHIC TERATOZOOSPERMIA, SHORT COMMUNICATION. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 13(1), 77-82. SID. https://sid.ir/paper/306030/en

Vancouver: Copy

DEHGHANPOUR FATEMEH, FESAHAT FARZANEH, MIRESMAEILI SEYED MOHSEN, ZARE MEHRJARDI EHSAN, HONARJU AHMAD, TALEBI ALI REZA. ANALYSIS OF PRM1 AND PRM2 POLYMORPHISMS IN IRANIAN INFERTILE MEN WITH IDIOPATHIC TERATOZOOSPERMIA, SHORT COMMUNICATION. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2019;13(1):77-82. Available from: https://sid.ir/paper/306030/en

IEEE: Copy

FATEMEH DEHGHANPOUR, FARZANEH FESAHAT, SEYED MOHSEN MIRESMAEILI, EHSAN ZARE MEHRJARDI, AHMAD HONARJU, and ALI REZA TALEBI, “ANALYSIS OF PRM1 AND PRM2 POLYMORPHISMS IN IRANIAN INFERTILE MEN WITH IDIOPATHIC TERATOZOOSPERMIA, SHORT COMMUNICATION,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 13, no. 1, pp. 77–82, 2019, [Online]. Available: https://sid.ir/paper/306030/en

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