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Information Journal Paper

Title

Toxoplasma Serology Status and Risk of Miscarriage, A Case-Control Study among Women with A History of Spontaneous Abortion

Pages

  184-189

Abstract

 Background: Toxoplasma gondii is one of the major causes of Abortion in pregnant women. Most cases of Abortion occur in the acute phase of infection and early Pregnancy. The purpose of this study was to investigate the association between spontaneous Abortion and seropositive status of Toxoplasmosis in women with first-time spontaneous Abortion. Materials and Methods: This research is a case-control study on 240 serum samples from women experiencing spontaneous Abortion for the first time as the case group, and 240 serum samples from women who had a normal delivery with no history of Abortion as the control group. The level of anti-Toxoplasma gondii IgM and IgG antibodies were assessed in serum samples using ELISA. To separate the acute and chronic infections, all IgM-positive samples in both groups and IgG-positive samples of the case group were examined using IgG Avidity. Results: The Toxoplasma IgM antibody was detected in 3. 3% (8/240) of the case group and 0. 4% (1/240) of the control group, which was a statistically significant difference between the two groups [P=0. 019, odds ratio (OR)=10. 266]. Of all samples 47. 5% and 46. 3% of the case and control groups were positive for Toxoplasma IgG antibody, respectively. Seven out of 8 (87. 5%) IgM-positive serum samples from the case group had low IgG Avidity, indicating acute infections, whereas all IgG-positive sera and 1 IgM-positive serum, which was related to the control group, showed a high IgG Avidity, indicating chronic infections. Conclusion: Maternal acute Toxoplasmosis during Pregnancy is raised as one of the factors that increase the chance of spontaneous Abortion. The necessary health training, especially on the parasite transmission ways to women before marriage, as well as the serological test in women before and during Pregnancy is recommended. Polymerase chain reaction (PCR) and IgG Avidity assays should be performed in the medical diagnostic laboratories for accurate distinguishing of the initial infection of Toxoplasmosis in the pregnant women.

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    APA: Copy

    KHEIRANDISH, FARNAZ, EZATPOUR, BEHROUZ, FALLAHI, SHIRZAD, TARAHI, MOHAMMAD JAVAD, Hosseini, Pardis, Karimi Rouzbahani, Arian, SEYYED TABAEI, SEYYED JAVAD, & AKBARI, SOHEILA. (2019). Toxoplasma Serology Status and Risk of Miscarriage, A Case-Control Study among Women with A History of Spontaneous Abortion. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 13(3), 184-189. SID. https://sid.ir/paper/306054/en

    Vancouver: Copy

    KHEIRANDISH FARNAZ, EZATPOUR BEHROUZ, FALLAHI SHIRZAD, TARAHI MOHAMMAD JAVAD, Hosseini Pardis, Karimi Rouzbahani Arian, SEYYED TABAEI SEYYED JAVAD, AKBARI SOHEILA. Toxoplasma Serology Status and Risk of Miscarriage, A Case-Control Study among Women with A History of Spontaneous Abortion. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2019;13(3):184-189. Available from: https://sid.ir/paper/306054/en

    IEEE: Copy

    FARNAZ KHEIRANDISH, BEHROUZ EZATPOUR, SHIRZAD FALLAHI, MOHAMMAD JAVAD TARAHI, Pardis Hosseini, Arian Karimi Rouzbahani, SEYYED JAVAD SEYYED TABAEI, and SOHEILA AKBARI, “Toxoplasma Serology Status and Risk of Miscarriage, A Case-Control Study among Women with A History of Spontaneous Abortion,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 13, no. 3, pp. 184–189, 2019, [Online]. Available: https://sid.ir/paper/306054/en

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