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Information Journal Paper

Title

Beneficial Effects of Oral Lactobacillus on Pain Severity in Women Suffering from Endometriosis: A Pilot Placebo-Controlled Randomized Clinical Trial

Pages

  178-183

Abstract

 Background: This study assessed the effects of a Lactobacillus-based medication on pain intensity scores in women with Endometriosis. Materials and Methods: The present randomized pilot placebo-controlled trial was done on eligible women who were surgically and pathologically diagnosed with Endometriosis. Thirty-seven participants who had not received hormonal treatment in the last three months, were enrolled and randomized into LactoFem® and placebo groups. Lactobacillus capsules or placebo were administrated orally once a day for 8 weeks. Patients were assessed for pain severity using Visual Analogue Scale (VAS) scores for Dysmenorrhea, Dyspareunia and Chronic Pelvic Pain at baseline and after 8 and 12 weeks post-intervention. Results: Mean age of participants and mean body mass index (BMI) for the LactoFem® and control groups were comparable. All patients had stage 3 and 4 of the disease based on revised American fertility society (AFS) classification of Endometriosis. Mean initial pain scores for Dysmenorrhea, Dyspareunia and Chronic Pelvic Pain were 6. 53 ± 2. 88, 4. 82 ± 3. 76 and 4. 19 ± 3. 53, respectively in the LactoFem® group and 5. 60 ± 2. 06, 3. 67 ± 2. 64 and 2. 88 ± 2. 80, respectively for the control group; the two groups had comparable scores in this regard. There was more decrease in pain scores for both Dysmenorrhea and the overall pain after 8 weeks of treatment in LactoFem® group compared to the control group. The scores for Dysmenorrhea were 6. 53 ± 2. 88 and 5. 60 ± 2. 06 in the LactoFem® and control groups, respectively, before intervention but, after 8-week treatment, these values were 3. 07 ± 2. 49 and 4. 47 ± 2. 13 (P=0. 018), respectively. The changes in overall pain score in the LactoFem® and control group during this period were 7. 33 ± 7. 00 and 4. 11 ± 1. 68, respectively (P=0. 017). Conclusion: This study showed some beneficial effects of Lactobacillus administration on Endometriosis-related pain (Registration number: IRCT20150819023684N5).

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    APA: Copy

    KHODAVERDI, SEPIDEH, Mohammadbeigi,, Robabeh, KHALEDI, MOJDEH, Mesdaghinia, Leila, SHARIFZADEH, FATEMEH, NASIRIPOUR, SOMAYYEH, & GORGINZADEH, MANSOUREH. (2019). Beneficial Effects of Oral Lactobacillus on Pain Severity in Women Suffering from Endometriosis: A Pilot Placebo-Controlled Randomized Clinical Trial. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 13(3), 178-183. SID. https://sid.ir/paper/306059/en

    Vancouver: Copy

    KHODAVERDI SEPIDEH, Mohammadbeigi, Robabeh, KHALEDI MOJDEH, Mesdaghinia Leila, SHARIFZADEH FATEMEH, NASIRIPOUR SOMAYYEH, GORGINZADEH MANSOUREH. Beneficial Effects of Oral Lactobacillus on Pain Severity in Women Suffering from Endometriosis: A Pilot Placebo-Controlled Randomized Clinical Trial. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2019;13(3):178-183. Available from: https://sid.ir/paper/306059/en

    IEEE: Copy

    SEPIDEH KHODAVERDI, Robabeh Mohammadbeigi,, MOJDEH KHALEDI, Leila Mesdaghinia, FATEMEH SHARIFZADEH, SOMAYYEH NASIRIPOUR, and MANSOUREH GORGINZADEH, “Beneficial Effects of Oral Lactobacillus on Pain Severity in Women Suffering from Endometriosis: A Pilot Placebo-Controlled Randomized Clinical Trial,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 13, no. 3, pp. 178–183, 2019, [Online]. Available: https://sid.ir/paper/306059/en

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