مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Effect of Single-Dose Methotrexate Treatment on Ovarian Reserve in Women with Ectopic Pregnancy Undergoing Infertility Treatment: A Single-Center Experience

Pages

  23-26

Abstract

 Background: The aim of this study was evaluation of the impact of single-dose Methotrexate (MTX) treatment on Ovarian Reserve in women with Ectopic Pregnancy (EP) undergoing infertility treatment in Iranian population. Materials and Methods: This prospective cohort study was done between March 2015 and March 2017 in Tehran General Women Hospital, Tehran, Iran. We enrolled 20 patients with EP who conceived during infertility treatment and received a single-dose MTX (50 mg/m 2 ) intramuscularly. Serum Anti-Mullerian Hormone (AMH), 17 beta-estradiol (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) on trans-vaginal ultrasonography, were evaluated before and 8 weeks after administration of MTX. Results: AMH did not significantly vary after the administration of MTX, compared to before treatment value (P=0. 36). FSH, E2 and AFC changes were not statistically significant, while increment of LH was significant (P=0. 02). Conclusion: Results indicated that single-dose MTX treatment did not reduce Ovarian Reserve in women with EP. Further randomized controlled clinical trial studies with larger sample sizes, by using multiple dosages of MTX, and with long-term follow up are suggested to be done.

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    APA: Copy

    SHIRAZI, MAHBOOBEH, POORANSARI, PARICHEHR, Hajiha, Neda, Shaker, Zeinab, Ghazi, Mohadeseh, DAVARI TANHA, FATEMEH, GHORBANI YEKTA, BATOOL, & GHAEMI, MARJAN. (2020). Effect of Single-Dose Methotrexate Treatment on Ovarian Reserve in Women with Ectopic Pregnancy Undergoing Infertility Treatment: A Single-Center Experience. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 14(1), 23-26. SID. https://sid.ir/paper/306086/en

    Vancouver: Copy

    SHIRAZI MAHBOOBEH, POORANSARI PARICHEHR, Hajiha Neda, Shaker Zeinab, Ghazi Mohadeseh, DAVARI TANHA FATEMEH, GHORBANI YEKTA BATOOL, GHAEMI MARJAN. Effect of Single-Dose Methotrexate Treatment on Ovarian Reserve in Women with Ectopic Pregnancy Undergoing Infertility Treatment: A Single-Center Experience. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2020;14(1):23-26. Available from: https://sid.ir/paper/306086/en

    IEEE: Copy

    MAHBOOBEH SHIRAZI, PARICHEHR POORANSARI, Neda Hajiha, Zeinab Shaker, Mohadeseh Ghazi, FATEMEH DAVARI TANHA, BATOOL GHORBANI YEKTA, and MARJAN GHAEMI, “Effect of Single-Dose Methotrexate Treatment on Ovarian Reserve in Women with Ectopic Pregnancy Undergoing Infertility Treatment: A Single-Center Experience,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 14, no. 1, pp. 23–26, 2020, [Online]. Available: https://sid.ir/paper/306086/en

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