LIFE SAVING PLASMAPHERESIS FOR THE MANAGEMENT OF HEMOLYTIC CRISIS AND ACUTE LIVER FAILURE IN WILSONS DISEASE

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PASHAEI M.R.; AZHDARKOSH H.; EBRAHIMI DARYANI NASER; HABIB ELAHI P.; BEYG MOHAMMADI M.T.

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Journal: Hepatitis Monthly Year:2009 | Volume:9 | Issue:2 (23) Page(s): 154-158

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Title

LIFE SAVING PLASMAPHERESIS FOR THE MANAGEMENT OF HEMOLYTIC CRISIS AND ACUTE LIVER FAILURE IN WILSONS DISEASE

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Keywords

WILSON'S DISEASE

PLASMAPHERESIS

ACUTE HEPATIC FAILURE

HEMOLYSIS

Abstract

WILSON'S DISEASE, caused by a deficient cellular copper export system, is transmitted as an autosomal recessive inherited disorder and results in copper accumulation in liver and other organs, particularly in brain. ACUTE HEPATIC FAILURE and severe Coombs' negative HEMOLYSIS may occur in the course of the disease which has a poor prognosis and most patients do not survive the crisis. Only liver transplantation has been recommended as an effective medical intervention. Herein, we presented a 25-year-old woman with impaired consciousness, ACUTE HEPATIC FAILURE and HEMOLYSIS that was treated with PLASMAPHERESIS and albumin replacement. Beside improvement in medical condition, serum copper and HEMOLYSIS decreased significantly and renal function was preserved. We concluded that PLASMAPHERESIS may be a life saving intervention during fulminant hepatic failure of WILSON'S DISEASE.

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APA: Copy

PASHAEI, M.R., AZHDARKOSH, H., EBRAHIMI DARYANI, NASER, HABIB ELAHI, P., & BEYG MOHAMMADI, M.T.. (2009). LIFE SAVING PLASMAPHERESIS FOR THE MANAGEMENT OF HEMOLYTIC CRISIS AND ACUTE LIVER FAILURE IN WILSONS DISEASE. HEPATITIS MONTHLY, 9(2 (23)), 154-158. SID. https://sid.ir/paper/306219/en

Vancouver: Copy

PASHAEI M.R., AZHDARKOSH H., EBRAHIMI DARYANI NASER, HABIB ELAHI P., BEYG MOHAMMADI M.T.. LIFE SAVING PLASMAPHERESIS FOR THE MANAGEMENT OF HEMOLYTIC CRISIS AND ACUTE LIVER FAILURE IN WILSONS DISEASE. HEPATITIS MONTHLY[Internet]. 2009;9(2 (23)):154-158. Available from: https://sid.ir/paper/306219/en

IEEE: Copy

M.R. PASHAEI, H. AZHDARKOSH, NASER EBRAHIMI DARYANI, P. HABIB ELAHI, and M.T. BEYG MOHAMMADI, “LIFE SAVING PLASMAPHERESIS FOR THE MANAGEMENT OF HEMOLYTIC CRISIS AND ACUTE LIVER FAILURE IN WILSONS DISEASE,” HEPATITIS MONTHLY, vol. 9, no. 2 (23), pp. 154–158, 2009, [Online]. Available: https://sid.ir/paper/306219/en

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