EFFICACY OF HEPATITIS B VACCINE IN THOSE WHO LOST HEPATITIS B SURFACE ANTIGEN DURING FOLLOW-UP

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TAHERI HASAN; HASANJANI ROUSHAN M.R.; SOLEYMANI AMIRI M.J.; POURALIJAN M.; BIJANI A.

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Journal: Hepatitis Monthly Year:2011 | Volume:11 | Issue:2 (31) Page(s): 119-122

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Title

EFFICACY OF HEPATITIS B VACCINE IN THOSE WHO LOST HEPATITIS B SURFACE ANTIGEN DURING FOLLOW-UP

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Keywords

CHRONIC HEPATITIS B

FOLLOW-UP STUDY

HBSAG

HEPATITIS B VIRUS

HEPATITIS B VACCINE

Abstract

Background: The level of HBSAG in some CHRONIC HEPATITIS B virus (HBV)-infected individuals may decline over time so that it is not detectable in serum.Objective: To assess the efficacy of HBV vaccine in those who lost their HBSAG without seroconverssion to anti-HBs antibody.Patients and Methods: From April 1993 to December 2008, of 1603 chronic HBV-infected individuals, 34 (22 men and 12 women) became HBSAG-negative in follow-up visits, with no detectable anti-HBs antibody and HBV DNA in their sera. They received HBV vaccination at 0, 1 and 6 months (case group). Fifty-two subjects (30 men and 22 women) who were negative for HBSAG, anti-HBs and anti-HBc antibody, received HBV vaccination according to the said schedule (control group). Anti-HBs antibody was assessed one month after the last dose of vaccination in the both groups. Results: The mean±SD age of the case and control groups was 38±12.7 and 33.4±8.6 years, respectively (p=0.07). The sex distribution between these two groups were similar (p=0.652). The mean±SD years of follow-up for the case group were 7.6±4.5 years. Anti-HBs antibody level ³10 IU/L was found in 8 (24%) subjects in the case group and in 45 (87%) in the control group (p<0.001). The mean±SD anti-HBs antibody level in the case group was 68±32.66 and in the control group 344.6±38.9 IU/L (p<0.001).Conclusions: We found that nearly 24% of chronic HBSAG-positive subjects who lost their HBSAG responded to HBV and the remaining cases need to be followed for occult HBV infection.

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APA: Copy

TAHERI, HASAN, HASANJANI ROUSHAN, M.R., SOLEYMANI AMIRI, M.J., POURALIJAN, M., & BIJANI, A.. (2011). EFFICACY OF HEPATITIS B VACCINE IN THOSE WHO LOST HEPATITIS B SURFACE ANTIGEN DURING FOLLOW-UP. HEPATITIS MONTHLY, 11(2 (31)), 119-122. SID. https://sid.ir/paper/306354/en

Vancouver: Copy

TAHERI HASAN, HASANJANI ROUSHAN M.R., SOLEYMANI AMIRI M.J., POURALIJAN M., BIJANI A.. EFFICACY OF HEPATITIS B VACCINE IN THOSE WHO LOST HEPATITIS B SURFACE ANTIGEN DURING FOLLOW-UP. HEPATITIS MONTHLY[Internet]. 2011;11(2 (31)):119-122. Available from: https://sid.ir/paper/306354/en

IEEE: Copy

HASAN TAHERI, M.R. HASANJANI ROUSHAN, M.J. SOLEYMANI AMIRI, M. POURALIJAN, and A. BIJANI, “EFFICACY OF HEPATITIS B VACCINE IN THOSE WHO LOST HEPATITIS B SURFACE ANTIGEN DURING FOLLOW-UP,” HEPATITIS MONTHLY, vol. 11, no. 2 (31), pp. 119–122, 2011, [Online]. Available: https://sid.ir/paper/306354/en

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