INCREASED LIVER STIFFNESS IN EXTRAHEPATIC CHOLESTASIS CAUSED BY CHOLEDOCHOLITHIASIS

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TRIFAN ANCA; SFARTI CATALIN; COJOCARIU CAMELIA; DIMACHE MIHAELA; CRETU MARIA; HUTANASU CATALIN; STANCIU CAROL

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Journal: Hepatitis Monthly Year:2011 | Volume:11 | Issue:5 (34) Page(s): 372-375

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Title

INCREASED LIVER STIFFNESS IN EXTRAHEPATIC CHOLESTASIS CAUSED BY CHOLEDOCHOLITHIASIS

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Keywords

EXTRAHEPATIC CHOLESTASIS

LIVER STIFFNESS

TRANSIENT ELASTOGRAPHY

Abstract

Background: EXTRAHEPATIC CHOLESTASIS that is caused by benign and malignant diseases has been reported to increase LIVER STIFFNESS (LS), as measured by TRANSIENT ELASTOGRAPHY (TE).Objectives: The aim of this study was to evaluate LS in patients with EXTRAHEPATIC CHOLESTASIS due to choledocholithiasis before and after endoscopic sphincterotomy and stone removal.Patients and Methods: LS was measured by TE (Fibroscan) in patients with EXTRAHEPATIC CHOLESTASIS that was caused by choledocholithiasis before and 1 month after endoscopic sphincterotomy and successful stone removal.Results: We studied 12 patients (7 females, 5 males), aged 36 to 76 years (mean age 57.1 ± 11.6 years), with EXTRAHEPATIC CHOLESTASIS that was caused by choledocholithiasis.LS was increased in all patients (range: 6.2–18.4 kPa; mean: 8.9 ± 3.5 kPa) before endoscopic therapy. Successful biliary drainage was effected by sphincterotomy and stone removal in all patients, which led to a significant decline in LS to 3.9–8.1 kPa (Mean: 5.6 ± 1.2 kPa; p<0.001) within a mean observation time of 29 days. The decrease in LS values correlated significantly with a decline in serum total bilirubin levels (r=0.691; p<0.0001).Conclusions: EXTRAHEPATIC CHOLESTASIS due to choledocholithiasis increases LS and should be excluded before assesing liver fibrosis by TRANSIENT ELASTOGRAPHY.

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APA: Copy

TRIFAN, ANCA, SFARTI, CATALIN, COJOCARIU, CAMELIA, DIMACHE, MIHAELA, CRETU, MARIA, HUTANASU, CATALIN, & STANCIU, CAROL. (2011). INCREASED LIVER STIFFNESS IN EXTRAHEPATIC CHOLESTASIS CAUSED BY CHOLEDOCHOLITHIASIS. HEPATITIS MONTHLY, 11(5 (34)), 372-375. SID. https://sid.ir/paper/306390/en

Vancouver: Copy

TRIFAN ANCA, SFARTI CATALIN, COJOCARIU CAMELIA, DIMACHE MIHAELA, CRETU MARIA, HUTANASU CATALIN, STANCIU CAROL. INCREASED LIVER STIFFNESS IN EXTRAHEPATIC CHOLESTASIS CAUSED BY CHOLEDOCHOLITHIASIS. HEPATITIS MONTHLY[Internet]. 2011;11(5 (34)):372-375. Available from: https://sid.ir/paper/306390/en

IEEE: Copy

ANCA TRIFAN, CATALIN SFARTI, CAMELIA COJOCARIU, MIHAELA DIMACHE, MARIA CRETU, CATALIN HUTANASU, and CAROL STANCIU, “INCREASED LIVER STIFFNESS IN EXTRAHEPATIC CHOLESTASIS CAUSED BY CHOLEDOCHOLITHIASIS,” HEPATITIS MONTHLY, vol. 11, no. 5 (34), pp. 372–375, 2011, [Online]. Available: https://sid.ir/paper/306390/en

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