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Information Journal Paper

Title

NEW POTENTIAL INSTRUMENT TO FIGHT HEPATOCELLULAR CANCER BY RESTORING P53

Pages

  331-332

Abstract

 Although the name for cancer as a disease was coined by ancient Greeks and Persians, and in spite of billions of euros, dollars, and other currencies invested in cancer research, the disease remains a major killer, particularly in Western countries (1). Over half of anticancer drugs, including acetogenins, alkaloids, and terpenes, are derived from natural products, especially from the plant kingdom (2-6). ANNONACEOUS ACETOGENINS (ACGs) include a series of natural products isolated from Annonaceae plants. ACGs are white, waxy derivatives of longchain (C35 or C37) fatty acids, characterized by a long aliphatic chain bearing a terminal methyl substituted a, b –unsaturated γ -lactone ring with one-, two- or three tetrahydropyran (THP) rings (5). ACGs are a likely source of potential drugs as they exhibit various biological activities such as cytotoxic, antitumor, antiparasitic, pesticidal, pisicidal, antihelmenthic, antiviral, antimicrobial, and immunosuppressive activities. They are known to be powerful inhibitors of complex I (NADH: biquinone oxidoreductases) in the mitochondrial electron transport system.

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    • Cite

    APA: Copy

    VINCENT, FRANKLIN C., & LOS, MAREK J.. (2011). NEW POTENTIAL INSTRUMENT TO FIGHT HEPATOCELLULAR CANCER BY RESTORING P53. HEPATITIS MONTHLY, 11(5 (34)), 331-332. SID. https://sid.ir/paper/306401/en

    Vancouver: Copy

    VINCENT FRANKLIN C., LOS MAREK J.. NEW POTENTIAL INSTRUMENT TO FIGHT HEPATOCELLULAR CANCER BY RESTORING P53. HEPATITIS MONTHLY[Internet]. 2011;11(5 (34)):331-332. Available from: https://sid.ir/paper/306401/en

    IEEE: Copy

    FRANKLIN C. VINCENT, and MAREK J. LOS, “NEW POTENTIAL INSTRUMENT TO FIGHT HEPATOCELLULAR CANCER BY RESTORING P53,” HEPATITIS MONTHLY, vol. 11, no. 5 (34), pp. 331–332, 2011, [Online]. Available: https://sid.ir/paper/306401/en

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