THE EFFECT OF GBV-C INFECTION ON CD4 COUNT AND VIRAL LOADS IN PATIENTS INFECTED WITH HIV

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KEYVANI HOSSEIN; MOHAMMADI AVID; SABOURI GHANNAD MASOUD; HAJABDOLBAGHI MAHBOOBEH

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Journal Paper

Paper Information

Journal: Hepatitis Monthly Year:2012 | Volume:12 | Issue:1 (42) Page(s): 38-41

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Title

THE EFFECT OF GBV-C INFECTION ON CD4 COUNT AND VIRAL LOADS IN PATIENTS INFECTED WITH HIV

Author(s)

KEYVANI HOSSEIN | MOHAMMADI AVID | SABOURI GHANNAD MASOUD | HAJABDOLBAGHI MAHBOOBEH | Issue Writer Certificate

Keywords

GB VIRUS C

HIV

INFECTION

CD4 LYMPHOCYTE COUNT

Abstract

Background: The picture that has emerged from studies investigating HIV infected people with GBV-C viremia is that they have lower plasma HIV viral loads in comparison with HIV-positive people who did not have the GBV-C viremia.Objectives: Since GBV-C HIV coinfection has not been studied in Iran, we have designed a survey to study the outcomes of GBV-C INFECTION on HIV infected individuals.Patients and Methods: We analyzed 78 serum samples from HIV-positive patients in Tehran. The HIV positive statue was confirmed by Western blot in our laboratory. Next we detected GBV-C RNA by RT nested-PCR and divided our patient into GBV-C positive and GBV-C negative groups. The final step was measuring the CD4 count and HIV viral load and comparing the means of the CD4 count and HIV viral load in HIV-infected individuals in the GBV-C positive and GBV-C negative groups.Results: We detected GBV-C RNA in 15 patients out of 78. The mean CD4 count was 607.13 compared to 415.87 in the GBV-C negative group and the difference was significant (P=0.005). In contrast to the CD4 count there was no significant difference in HIV viral loads between HIV infected individuals in the GBV-C positive and GBV-C negative groups.Conclusion: Although there was no significant difference in the mean of the HIV viral load between the GBV-C positive and GBV-C negative groups, the significantly higher CD4 mean in the GBV-C positive group compared with the GBV-C negative group suggests a beneficial effect of this coinfection.

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APA: Copy

KEYVANI, HOSSEIN, MOHAMMADI, AVID, SABOURI GHANNAD, MASOUD, & HAJABDOLBAGHI, MAHBOOBEH. (2012). THE EFFECT OF GBV-C INFECTION ON CD4 COUNT AND VIRAL LOADS IN PATIENTS INFECTED WITH HIV. HEPATITIS MONTHLY, 12(1 (42)), 38-41. SID. https://sid.ir/paper/306505/en

Vancouver: Copy

KEYVANI HOSSEIN, MOHAMMADI AVID, SABOURI GHANNAD MASOUD, HAJABDOLBAGHI MAHBOOBEH. THE EFFECT OF GBV-C INFECTION ON CD4 COUNT AND VIRAL LOADS IN PATIENTS INFECTED WITH HIV. HEPATITIS MONTHLY[Internet]. 2012;12(1 (42)):38-41. Available from: https://sid.ir/paper/306505/en

IEEE: Copy

HOSSEIN KEYVANI, AVID MOHAMMADI, MASOUD SABOURI GHANNAD, and MAHBOOBEH HAJABDOLBAGHI, “THE EFFECT OF GBV-C INFECTION ON CD4 COUNT AND VIRAL LOADS IN PATIENTS INFECTED WITH HIV,” HEPATITIS MONTHLY, vol. 12, no. 1 (42), pp. 38–41, 2012, [Online]. Available: https://sid.ir/paper/306505/en

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