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Information Journal Paper

Title

HEME OXYGENASE-1 MRNA EXPRESSION IN EGYPTIAN PATIENTS WITH CHRONIC LIVER DISEASE

Pages

  278-285

Abstract

 Background: Chronic liver disease (CLD) is a global medical problem. This disease is associated with increased hepatic OXIDATIVE STRESS. One of the antioxidant enzymes that protect cells against this stress is HEME OXYGENASE-1 (HO-1).Objectives: This study aimed to investigate the mRNA expression of HO-1 in Egyptian patients with CLD and its relation to OXIDATIVE STRESS biomarkers.Patients and Methods: Levels of serum ferritin, carboxy hemoglobin, malondialdehyde (MDA), and erythrocyte-reduced glutathione (GSH) were measured, and HO-1 mRNA expression was detected in 45 CLD patients (15 with nonalcoholic steatohepatitis [NASH], 15 with chronic hepatitis C, and 15 with LIVER CIRRHOSIS) and 15 healthy controls.Results: HO-1 mRNA expression was increased in patients with NASH, chronic hepatitis C, and LIVER CIRRHOSIS compared to controls. The expression in cirrhotic patients was significantly higher than that in patients with NASH and chronic hepatitis C. Compared to controls, patients with NASH, chronic hepatitis C, and LIVER CIRRHOSIS had higher levels of ferritin, carboxy hemoglobin, and MDA and lower levels of GSH. HO-1 mRNA expression was positively correlated with levels of carboxy hemoglobin, serum ferritin, and serum MDA and negatively correlated with levels of erythrocyte GSH in CLD patients.Conclusions: HO-1 mRNA expression was significantly increased in CLD patients, and the increase reflected the severity of the disease. The significant relationship between the increased HO-1 expression and OXIDATIVE STRESS biomarkers in patients with CLD suggests that HO-1 may play an important role in protecting the liver from OXIDATIVE STRESS dependent damage. Therefore, induction of HO-1 could be a novel therapeutic option for CLD.

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  • Cite

    APA: Copy

    SAAD EL DIN BESSA, SAHAR, MOHAMED ALI, EHAB MOSTAFA, EL SAYED ABD EL WAHAB, ABEER, & NOR EL DIN, SHERIF ABD EL MONEM. (2012). HEME OXYGENASE-1 MRNA EXPRESSION IN EGYPTIAN PATIENTS WITH CHRONIC LIVER DISEASE. HEPATITIS MONTHLY, 12(4), 278-285. SID. https://sid.ir/paper/306536/en

    Vancouver: Copy

    SAAD EL DIN BESSA SAHAR, MOHAMED ALI EHAB MOSTAFA, EL SAYED ABD EL WAHAB ABEER, NOR EL DIN SHERIF ABD EL MONEM. HEME OXYGENASE-1 MRNA EXPRESSION IN EGYPTIAN PATIENTS WITH CHRONIC LIVER DISEASE. HEPATITIS MONTHLY[Internet]. 2012;12(4):278-285. Available from: https://sid.ir/paper/306536/en

    IEEE: Copy

    SAHAR SAAD EL DIN BESSA, EHAB MOSTAFA MOHAMED ALI, ABEER EL SAYED ABD EL WAHAB, and SHERIF ABD EL MONEM NOR EL DIN, “HEME OXYGENASE-1 MRNA EXPRESSION IN EGYPTIAN PATIENTS WITH CHRONIC LIVER DISEASE,” HEPATITIS MONTHLY, vol. 12, no. 4, pp. 278–285, 2012, [Online]. Available: https://sid.ir/paper/306536/en

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