Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

393
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

504
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

THE IFN-λ GENETIC POLYMORPHISM ASSOCIATION WITH THE VIRAL CLEARANCE INDUCED BY HEPATITIS C VIRUS TREATMENT IN PAKISTANI PATIENTS

Pages

  1-13

Abstract

 Background: POLYMORPHISMs in the interferon l (INF l) genes on chromosome 19 have been associated with clearance of hepatitis C virus (HCV) induced by interferon and RIBAVIRIN therapy however there is no such data available for Pakistani patients with HCV infection.Objectives: In this study, the effects of SINGLE NUCLEOTIDE POLYMORPHISMs (SNPs) have been investigated in response to treatment with interferon-a and RIBAVIRIN in a cohort of 75 HCV genotype 3a patients.Patients and Methods: A total number of 50 SNPs from the Interferon l region on chromosome 19 were genotyped to investigate allelic associations with the treatment response in HCV type 3a patients. Thirteen SNPs were associated with HCV clearance, with the most significant alleles being RS8109886 (Fisher's P=0.0001), RS8113007 (Fisher's P=0.0001) and RS12979860 (Fisher's P=0.0002).Results: These SNPs were found to be the most suitable SNPs for predicting treatment response in the present study. These findings support those reported previously. This could be used to improve HCV treatment strategies and suggest that Pakistani patients should be genotyped for the relevant SNPs to identify the patients who are more likely to respond to interferon and RIBAVIRIN therapy.Conclusions: This therapy is costly and can be accompanied by several adverse side-effects, hence pre-treatment prediction of patients who are most likely to benefit would have both economic and patient benefits in the long term.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    TIPU, IMRAN, MARRIAGE, FIONA, FAROOQI, ZIA UR RAHMAN, PLATT, HAZEL, ATHAR, MUHAMMAD AMIN, DAY, PHILIP JOHN, & SHORT, ANDREA. (2014). THE IFN-λ GENETIC POLYMORPHISM ASSOCIATION WITH THE VIRAL CLEARANCE INDUCED BY HEPATITIS C VIRUS TREATMENT IN PAKISTANI PATIENTS. HEPATITIS MONTHLY, 14(3), 1-13. SID. https://sid.ir/paper/306568/en

    Vancouver: Copy

    TIPU IMRAN, MARRIAGE FIONA, FAROOQI ZIA UR RAHMAN, PLATT HAZEL, ATHAR MUHAMMAD AMIN, DAY PHILIP JOHN, SHORT ANDREA. THE IFN-λ GENETIC POLYMORPHISM ASSOCIATION WITH THE VIRAL CLEARANCE INDUCED BY HEPATITIS C VIRUS TREATMENT IN PAKISTANI PATIENTS. HEPATITIS MONTHLY[Internet]. 2014;14(3):1-13. Available from: https://sid.ir/paper/306568/en

    IEEE: Copy

    IMRAN TIPU, FIONA MARRIAGE, ZIA UR RAHMAN FAROOQI, HAZEL PLATT, MUHAMMAD AMIN ATHAR, PHILIP JOHN DAY, and ANDREA SHORT, “THE IFN-λ GENETIC POLYMORPHISM ASSOCIATION WITH THE VIRAL CLEARANCE INDUCED BY HEPATITIS C VIRUS TREATMENT IN PAKISTANI PATIENTS,” HEPATITIS MONTHLY, vol. 14, no. 3, pp. 1–13, 2014, [Online]. Available: https://sid.ir/paper/306568/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top