DONOR REJECTION BEFORE LIVING DONOR LIVER TRANSPLANTATION: CAUSES AND COST EFFECTIVE ANALYSIS IN AN EGYPTIAN TRANSPLANT CENTER

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EL METEINI MAHMOUD; DABBOUS HANY; SAKR MOHAMMAD; IBRAHIM AMANY; FAWZY IMAN; BAHAA MOHAMED; ABDELAAL AMR; FATHY MOHAMED; SAID HANY; RADY MOHAMED; EL DORRY AHMED

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Journal: Hepatitis Monthly Year:2014 | Volume:14 | Issue:1 Page(s): 1-6

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Title

DONOR REJECTION BEFORE LIVING DONOR LIVER TRANSPLANTATION: CAUSES AND COST EFFECTIVE ANALYSIS IN AN EGYPTIAN TRANSPLANT CENTER

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LIVER TRANSPLANTATION

TISSUE DONORS

Abstract

Background: In the living donor liver transplant setting, the preoperative assessment of potential donors is important to ensure the donor safety.Objectives: The aim of this study was to identify causes and costs of living liver-donors rejection in the donation process.Materials and Methods: From June 2010 to June 2012, all potential living liver donors for 66 liver transplant candidates were screened at the Ain Shams Center for Organ Transplantation. Potential donors were evaluated in 3 phases, and their data were reviewed to determine the causes and at which phase the donors were rejected.Results: One hundred and ninety two potential living liver donors, including 157 (81.7%) males, were screened for 66 potential recipients. Of these, 126 (65.6%) were disqualified for the donation. The causes of rejection were classified as surgical (9.5 %) or medical (90.5 %). Five donors (3.9 %) were rejected due to multiple causes. Factor V Leiden mutation was detected in 29 (23 %) rejected donors (P=0.001), 25 (19.8 %) donors had positive results for hepatitis serology (P=0.005), and 16 (12.7 %) tested positive for drug abuse. Portal vein trifurcation (n=9, 7.1%) and small size liver graft estimated by CT volumetric analysis (n=6, 4.8 %) were the main surgical causes which precluded the donation.Conclusions: Among potential Egyptian living liver donors, Factor V Leiden mutation was a significant cause for live donor rejection. A stepwise approach to donor assessment was found to be cost-effective.

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APA: Copy

EL METEINI, MAHMOUD, DABBOUS, HANY, SAKR, MOHAMMAD, IBRAHIM, AMANY, FAWZY, IMAN, BAHAA, MOHAMED, ABDELAAL, AMR, FATHY, MOHAMED, SAID, HANY, RADY, MOHAMED, & EL DORRY, AHMED. (2014). DONOR REJECTION BEFORE LIVING DONOR LIVER TRANSPLANTATION: CAUSES AND COST EFFECTIVE ANALYSIS IN AN EGYPTIAN TRANSPLANT CENTER. HEPATITIS MONTHLY, 14(1), 1-6. SID. https://sid.ir/paper/306593/en

Vancouver: Copy

EL METEINI MAHMOUD, DABBOUS HANY, SAKR MOHAMMAD, IBRAHIM AMANY, FAWZY IMAN, BAHAA MOHAMED, ABDELAAL AMR, FATHY MOHAMED, SAID HANY, RADY MOHAMED, EL DORRY AHMED. DONOR REJECTION BEFORE LIVING DONOR LIVER TRANSPLANTATION: CAUSES AND COST EFFECTIVE ANALYSIS IN AN EGYPTIAN TRANSPLANT CENTER. HEPATITIS MONTHLY[Internet]. 2014;14(1):1-6. Available from: https://sid.ir/paper/306593/en

IEEE: Copy

MAHMOUD EL METEINI, HANY DABBOUS, MOHAMMAD SAKR, AMANY IBRAHIM, IMAN FAWZY, MOHAMED BAHAA, AMR ABDELAAL, MOHAMED FATHY, HANY SAID, MOHAMED RADY, and AHMED EL DORRY, “DONOR REJECTION BEFORE LIVING DONOR LIVER TRANSPLANTATION: CAUSES AND COST EFFECTIVE ANALYSIS IN AN EGYPTIAN TRANSPLANT CENTER,” HEPATITIS MONTHLY, vol. 14, no. 1, pp. 1–6, 2014, [Online]. Available: https://sid.ir/paper/306593/en

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