RAPAMYCIN ENHANCES HBV PRODUCTION BY INDUCING CELLULAR AUTOPHAGY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HUANG WENJUAN; ZHAO FENGRONG; HUANG YING; LI XIA; ZHU SUFEI; HU QIN; CHEN WEIXIAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Hepatitis Monthly Year:2014 | Volume:14 | Issue:10 Page(s): 0-0

Download Full-Text

View:

280

Download:

156

Cites:

Information Journal Paper

Title

RAPAMYCIN ENHANCES HBV PRODUCTION BY INDUCING CELLULAR AUTOPHAGY

Author(s)

Keywords

HBV

RAPAMYCIN

AUTOPHAGY

Abstract

Background: Some reports revealed that RAPAMYCIN could reactivate HBV infection. However, the mechanism has not been clearly explained.Objectives: In this report, we studied the mechanism by which RAPAMYCIN enhances HBV replication and expression by inducing cellular AUTOPHAGY.Materials and Methods: HepG2.2.15 cells were treated with RAPAMYCIN to induce AUTOPHAGY. Autophagosomes were observed by fluorescence microscopy and transmission electron microscopy. AUTOPHAGY marker protein LC3-II/LC3-Iwas detected by Western blotting. HBV DNA and mRNA were determined by real time PCR and Southern blotting. HBsAg was evaluated by ELISA.Results: In HepG2.2.15 cells, HBV DNA and HBsAg increased when host cells were treated with RAPAMYCIN and the effect was reversed by AUTOPHAGY inhibitor, 3-methyladenine (3-MA).Conclusions: These results indicated a potential explanation for reactivation of HBV infection when patients with hepatitis receive RAPAMYCIN

Cites

No record.

References

No record.

Cite

APA: Copy

HUANG, WENJUAN, ZHAO, FENGRONG, HUANG, YING, LI, XIA, ZHU, SUFEI, HU, QIN, & CHEN, WEIXIAN. (2014). RAPAMYCIN ENHANCES HBV PRODUCTION BY INDUCING CELLULAR AUTOPHAGY. HEPATITIS MONTHLY, 14(10), 0-0. SID. https://sid.ir/paper/306608/en

Vancouver: Copy

HUANG WENJUAN, ZHAO FENGRONG, HUANG YING, LI XIA, ZHU SUFEI, HU QIN, CHEN WEIXIAN. RAPAMYCIN ENHANCES HBV PRODUCTION BY INDUCING CELLULAR AUTOPHAGY. HEPATITIS MONTHLY[Internet]. 2014;14(10):0-0. Available from: https://sid.ir/paper/306608/en

IEEE: Copy

WENJUAN HUANG, FENGRONG ZHAO, YING HUANG, XIA LI, SUFEI ZHU, QIN HU, and WEIXIAN CHEN, “RAPAMYCIN ENHANCES HBV PRODUCTION BY INDUCING CELLULAR AUTOPHAGY,” HEPATITIS MONTHLY, vol. 14, no. 10, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/306608/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops