EFFECTS OF THE CHEMOKINE RECEPTOR 5 (CCR5)-DELTA32 MUTATION ON HEPATITIS C VIRUS-SPECIFIC IMMUNE RESPONSES AND LIVER TISSUE PATHOLOGY IN HCV INFECTED PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

YILMAZ ABDULKERIM; ALAGOZLU HAKAN; OZDEMIR OZTURK; ARICI SEMA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Hepatitis Monthly Year:2014 | Volume:14 | Issue:7 Page(s): 0-0

Download Full-Text

View:

298

Download:

215

Cites:

Information Journal Paper

Title

EFFECTS OF THE CHEMOKINE RECEPTOR 5 (CCR5)-DELTA32 MUTATION ON HEPATITIS C VIRUS-SPECIFIC IMMUNE RESPONSES AND LIVER TISSUE PATHOLOGY IN HCV INFECTED PATIENTS

Author(s)

YILMAZ ABDULKERIM | ALAGOZLU HAKAN | OZDEMIR OZTURK | ARICI SEMA | Issue Writer Certificate

Keywords

CHEMOKINES

HEPATITIS C VIRUS

INFECTION

Abstract

Background: The specific antiviral T cells provide CC chemokine receptor 5 (CCR5) for the immune response during the HEPATITIS C VIRUS (HCV) INFECTION. Heterogenous and/or homozygous 32 base pair deletion in CCR5 gene (CCR5D32 bpdel) leads to reduced protein expression.Objectives: In the current case control study, we aimed to compare the histopathological findings of liver to the CCR5D32 bpdel mutation profiles, expression and some other clinical findings in patients with chronic HCV INFECTION.Materials and Methods: Multiple Strip Assay reverse hybridisation and Real Time PCR techniques were used to determine the germline CCR5 mutations and immunohistochemical technique was used to evaluate the gene expression in targer tissue biopsies.Results: Target CCR5 WT/WT, WT/D32, and D32/D32 genotypes were observed in 91.4%, 8.6% and 0.0% for HCV positive patients and 98.3%, 1.7% and 0.0% for control group respectively. The histologic activity index (HAI) was significantly lower (4.0±1.0) in the mutated group than the non-mutated group (5.7±1.0). Decreased fibrosis levels were detected in HCV positive mutated group.Conclusions: Results showed that CCR5 polymorphism was more frequent in HCV positive patients than in healthy population in Turkish population. Current results also showed that mutated CCR5 signalling pathway due to CCR5-Delta32 may potentially result in subtle reduction of HCV specifity to the drug responses due to the positive impact on liver inflammation, fibrosis levels and liver destruction in HCV INFECTION.

Cites

No record.

References

No record.

Cite

APA: Copy

YILMAZ, ABDULKERIM, ALAGOZLU, HAKAN, OZDEMIR, OZTURK, & ARICI, SEMA. (2014). EFFECTS OF THE CHEMOKINE RECEPTOR 5 (CCR5)-DELTA32 MUTATION ON HEPATITIS C VIRUS-SPECIFIC IMMUNE RESPONSES AND LIVER TISSUE PATHOLOGY IN HCV INFECTED PATIENTS. HEPATITIS MONTHLY, 14(7), 0-0. SID. https://sid.ir/paper/306610/en

Vancouver: Copy

YILMAZ ABDULKERIM, ALAGOZLU HAKAN, OZDEMIR OZTURK, ARICI SEMA. EFFECTS OF THE CHEMOKINE RECEPTOR 5 (CCR5)-DELTA32 MUTATION ON HEPATITIS C VIRUS-SPECIFIC IMMUNE RESPONSES AND LIVER TISSUE PATHOLOGY IN HCV INFECTED PATIENTS. HEPATITIS MONTHLY[Internet]. 2014;14(7):0-0. Available from: https://sid.ir/paper/306610/en

IEEE: Copy

ABDULKERIM YILMAZ, HAKAN ALAGOZLU, OZTURK OZDEMIR, and SEMA ARICI, “EFFECTS OF THE CHEMOKINE RECEPTOR 5 (CCR5)-DELTA32 MUTATION ON HEPATITIS C VIRUS-SPECIFIC IMMUNE RESPONSES AND LIVER TISSUE PATHOLOGY IN HCV INFECTED PATIENTS,” HEPATITIS MONTHLY, vol. 14, no. 7, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/306610/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops