PLASMA INTERLEUKIN-10: A LIKELY PREDICTIVE MARKER FOR HEPATITIS B VIRUS-RELATED ACUTE-ON-CHRONIC LIVER FAILURE

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WANG KE; WU ZHE-BIN; YE YI NONG; LIU JING; ZHANG GENG LIN; SU YU JIE; HE HONG LIANG; ZHENG YU BAO; GAO ZHI LIANG

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Journal: Hepatitis Monthly Year:2014 | Volume:14 | Issue:7 Page(s): 0-0

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Title

PLASMA INTERLEUKIN-10: A LIKELY PREDICTIVE MARKER FOR HEPATITIS B VIRUS-RELATED ACUTE-ON-CHRONIC LIVER FAILURE

Author(s)

Keywords

CHRONIC HEPATITIS B

SEVERE EXACERBATION

CHRONIC LIVER FAILURE

CYTOKINES

INTERLEUKIN-10

Abstract

Background: The pathogenesis of HBV-related acute-on-chronic liver failure (HBV-ACLF) is mainly based on a heightened immune-inflammatory reaction; however, the intimate underlying mechanism remains unclear.Objectives: The aim of the study was to explore potential key immune molecular targets that could serve as early predictive markers for HBV-ACLF.Patients and Methods: Twenty-seven patients with acute exacerbation of CHRONIC HEPATITIS B (CHB) (defined by: alanine transaminase ³20 ULN, total bilirubin ³5 ULN, 40%< prothrombin time activity £ 60%) and without cirrhosis were divided into 18 cases which did not progress to HBV-ACLF (defined by: prothrombin time activity < 40% and development within four weeks of hepatic encephalopathy and/or ascites) and nine cases that developed HBV-ACLF. Nine healthy people defined the normal control group (NC). Interleukin-1b (IL-1b), IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, TNF-a and IFN-g protein levels were assayed by Cytometric Bead Array (CBA) in blood plasma. The ELISA method was applied to confirm IL-10 detection using the CBA method.Results: IL-4, IL-12p70 and IFN-g were undetectable; IL-1b, IL-6, IL-8, IL-10 and TNF-a levels were significantly higher than in NC. Moreover, CYTOKINES reached the highest levels in acute exacerbation of CHB, with the exception of IL-2 and IL-8. When comparing the HBV-ACLF patients prior to and at the time of ACLF diagnosis, IL-10 was the only cytokine that exhibited a significant decrease (P=0.008). IL-10 concentrations were positively correlated to ALT levels (r=0.711, P<0.001).Conclusions: The assessment of plasma IL-10 levels in CHRONIC HEPATITIS B acute exacerbation may provide an early predictive marker for progression to HBV-ACLF.

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APA: Copy

WANG, KE, WU, ZHE-BIN, YE, YI NONG, LIU, JING, ZHANG, GENG LIN, SU, YU JIE, HE, HONG LIANG, ZHENG, YU BAO, & GAO, ZHI LIANG. (2014). PLASMA INTERLEUKIN-10: A LIKELY PREDICTIVE MARKER FOR HEPATITIS B VIRUS-RELATED ACUTE-ON-CHRONIC LIVER FAILURE. HEPATITIS MONTHLY, 14(7), 0-0. SID. https://sid.ir/paper/306614/en

Vancouver: Copy

WANG KE, WU ZHE-BIN, YE YI NONG, LIU JING, ZHANG GENG LIN, SU YU JIE, HE HONG LIANG, ZHENG YU BAO, GAO ZHI LIANG. PLASMA INTERLEUKIN-10: A LIKELY PREDICTIVE MARKER FOR HEPATITIS B VIRUS-RELATED ACUTE-ON-CHRONIC LIVER FAILURE. HEPATITIS MONTHLY[Internet]. 2014;14(7):0-0. Available from: https://sid.ir/paper/306614/en

IEEE: Copy

KE WANG, ZHE-BIN WU, YI NONG YE, JING LIU, GENG LIN ZHANG, YU JIE SU, HONG LIANG HE, YU BAO ZHENG, and ZHI LIANG GAO, “PLASMA INTERLEUKIN-10: A LIKELY PREDICTIVE MARKER FOR HEPATITIS B VIRUS-RELATED ACUTE-ON-CHRONIC LIVER FAILURE,” HEPATITIS MONTHLY, vol. 14, no. 7, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/306614/en

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