CORRELATION BETWEEN PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 3 GENE POLYMORPHISMS AND LIVER CIRRHOSIS IN A CHINESE HAN POPULATION WITH CHRONIC HEPATITIS B

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TONG JIN; GUO JINJUN; HU JUN; HOU SIHUI; ZHANG YU; LI QINGLING

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Journal: Hepatitis Monthly Year:2014 | Volume:14 | Issue:8 Page(s): 0-0

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Title

CORRELATION BETWEEN PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 3 GENE POLYMORPHISMS AND LIVER CIRRHOSIS IN A CHINESE HAN POPULATION WITH CHRONIC HEPATITIS B

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Keywords

HEPATITIS B

CHRONIC

LIVER CIRRHOSIS

SINGLE NUCLEOTIDE POLYMORPHISMS

Abstract

Background: A single nucleotide polymorphism (SNP) of patatin-like phospholipase domain-containing 3 (PNPLA3) genes (rs738409) is associated with the severity of fibrosis and cirrhosis in patients with fatty liver disease. However, in a small group of Italian patients, there was no significant correlation between the rs738409 SNP and HEPATITIS B virus (HBV) infection-associated LIVER CIRRHOSIS.Objectives: This study aimed to investigate whether PNPLA3 polymorphisms are a risk factor for LIVER CIRRHOSIS in a Chinese Han population with CHRONIC HEPATITIS B (CHB).Patients and Methods: The study population consisted of 344 Chinese Han patients with CHB, among which 203 presented with LIVER CIRRHOSIS (LC group) and 141 had no sign of LIVER CIRRHOSIS (CHB group). TaqMan genotyping assay was used to investigate the association of two PNPLA3 SNPs (rs738409 and rs2281135) with the risk of LIVER CIRRHOSIS.Results: The allele and genotype distributions of PNPLA3 rs738409 and rs2281135 were not significantly different between the CHB and LC groups. After segregation on the basis of sex, no significant correlation between PNPLA3 (rs738409 and rs2281135) genotypes/alleles and LIVER CIRRHOSIS was detected. Moreover, none of the haplotypes in PNPLA3 (rs738409 and rs2281135) was found to be statistically different between the two groups.Conclusions: Our results showed no association between PNPLA3 polymorphisms (rs738409 and rs2281135) and the susceptibility to HBV-related LIVER CIRRHOSIS in a Chinese Han population.

Cites

ASSOCIATION OF PNPLA3 I148M VARIANT WITH CHRONIC VIRAL HEPATITIS, AUTOIMMUNE LIVER DISEASES AND OUTCOMES OF LIVER TRANSPLANTATION

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APA: Copy

TONG, JIN, GUO, JINJUN, HU, JUN, HOU, SIHUI, ZHANG, YU, & LI, QINGLING. (2014). CORRELATION BETWEEN PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 3 GENE POLYMORPHISMS AND LIVER CIRRHOSIS IN A CHINESE HAN POPULATION WITH CHRONIC HEPATITIS B. HEPATITIS MONTHLY, 14(8), 0-0. SID. https://sid.ir/paper/306626/en

Vancouver: Copy

TONG JIN, GUO JINJUN, HU JUN, HOU SIHUI, ZHANG YU, LI QINGLING. CORRELATION BETWEEN PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 3 GENE POLYMORPHISMS AND LIVER CIRRHOSIS IN A CHINESE HAN POPULATION WITH CHRONIC HEPATITIS B. HEPATITIS MONTHLY[Internet]. 2014;14(8):0-0. Available from: https://sid.ir/paper/306626/en

IEEE: Copy

JIN TONG, JINJUN GUO, JUN HU, SIHUI HOU, YU ZHANG, and QINGLING LI, “CORRELATION BETWEEN PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 3 GENE POLYMORPHISMS AND LIVER CIRRHOSIS IN A CHINESE HAN POPULATION WITH CHRONIC HEPATITIS B,” HEPATITIS MONTHLY, vol. 14, no. 8, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/306626/en

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