HLA-DPB1 VARIANT EFFECT ON HEPATITIS B VIRUS CLEARANCE AND LIVER CIRRHOSIS DEVELOPMENT AMONG SOUTHWEST CHINESE POPULATION

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HU ZHANGYONG; YANG JUN; XIONG GUOLIAN; SHI HAN; YUAN YUAN; FAN LIN; WANG YALI

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Journal: Hepatitis Monthly Year:2014 | Volume:14 | Issue:8 Page(s): 0-0

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Title

HLA-DPB1 VARIANT EFFECT ON HEPATITIS B VIRUS CLEARANCE AND LIVER CIRRHOSIS DEVELOPMENT AMONG SOUTHWEST CHINESE POPULATION

Author(s)

Keywords

HEPATITIS B VIRUS

SINGLE NUCLEOTIDE POLYMORPHISM

HUMAN

LEUKOCYTE

ANTIGEN

Abstract

Background: Previous studies have shown that genetic variants in HLA-DP genes affect disease progression in HEPATITIS B VIRUS (HBV) infection.Objectives: We aimed to evaluate possible association between HLA-DPB1 rs9277534 polymorphism and different clinical complications of HEPATITIS B VIRUS (HBV) infection.Materials and Methods: Snapshot assay was used to investigate the association of rs9277534 polymorphism in 342 patients with persistent HBV infection and 342 age and gender-matched HBV spontaneous clearance controls. Patients were categorized into asymptomatic HBV carriers (AsC, n=104), chronic hepatitis B (CHB, n=116), and liver cirrhosis (LC, n=122) subgroups.Results: There was a significantly higher proportion of the rs9277534 minor allele A in HBV spontaneous clearance control than that in HBV persistent infection group (OR=0.58, 95%CI=0.46-0.73, P<0.0001). Genotypic analysis showed that GA and AA genotypes were associated with HBV spontaneous clearance (GA: OR=0.56, 95%CI=0.40-0.79, P=0.019; AA: OR=0.24, 95%CI=0.14-0.44, P<0.0001). A significant difference was found between AsC and LC groups in the distribution of AA genotype (OR=9.32, 95%CI=1.293-67.14, P=0.027).Conclusions: Variant at rs9277534 could affect both the spontaneous clearance of HBV infection and progression from asymptomatic HBV carriers to HBV-related liver cirrhosis in Southwest Han Chinese population.

Cites

PREVALENCE OF HEPATITIS B AND KNOWLEDGE ABOUT HEPATITIS B AMONG MIGRANT WORKERS IN SHANDONG PROVINCE, CHINA: A CROSS-SECTIONAL STUDY

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APA: Copy

HU, ZHANGYONG, YANG, JUN, XIONG, GUOLIAN, SHI, HAN, YUAN, YUAN, FAN, LIN, & WANG, YALI. (2014). HLA-DPB1 VARIANT EFFECT ON HEPATITIS B VIRUS CLEARANCE AND LIVER CIRRHOSIS DEVELOPMENT AMONG SOUTHWEST CHINESE POPULATION. HEPATITIS MONTHLY, 14(8), 0-0. SID. https://sid.ir/paper/306628/en

Vancouver: Copy

HU ZHANGYONG, YANG JUN, XIONG GUOLIAN, SHI HAN, YUAN YUAN, FAN LIN, WANG YALI. HLA-DPB1 VARIANT EFFECT ON HEPATITIS B VIRUS CLEARANCE AND LIVER CIRRHOSIS DEVELOPMENT AMONG SOUTHWEST CHINESE POPULATION. HEPATITIS MONTHLY[Internet]. 2014;14(8):0-0. Available from: https://sid.ir/paper/306628/en

IEEE: Copy

ZHANGYONG HU, JUN YANG, GUOLIAN XIONG, HAN SHI, YUAN YUAN, LIN FAN, and YALI WANG, “HLA-DPB1 VARIANT EFFECT ON HEPATITIS B VIRUS CLEARANCE AND LIVER CIRRHOSIS DEVELOPMENT AMONG SOUTHWEST CHINESE POPULATION,” HEPATITIS MONTHLY, vol. 14, no. 8, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/306628/en

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