HCV NS3 BLOCKING EFFECT ON IFN INDUCED ISGS LIKE VIPERIN AND IL28 WITH AND WITHOUT NS4A

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KHANLARI ZAHRA; SABAHI FARZANEH; HOSSEINI SEYED YOUNES; GHADERI MOSTAFA

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Journal: Hepatitis Monthly Year:2014 | Volume:14 | Issue:6 Page(s): 0-0

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Title

HCV NS3 BLOCKING EFFECT ON IFN INDUCED ISGS LIKE VIPERIN AND IL28 WITH AND WITHOUT NS4A

Author(s)

KHANLARI ZAHRA | SABAHI FARZANEH | HOSSEINI SEYED YOUNES | GHADERI MOSTAFA | Issue Writer Certificate

Keywords

HEPATITIS C

NS3

INTERFERON-LAMBDA PROTEIN

Abstract

Background: HEPATITIS C virus (HCV) is able to down-regulate innate immune response. It is important to know the immune pathways that this virus interacts with. HCV non-structural protein 3 (NS3) plays an important role in this viral feature. HCV NS3 protein could affect the expression of antiviral protein such as viperin, and interleukin 28whichare important proteins in antiviral response.Objectives: HCV has developed different mechanisms to maintain a persistent infection, especially by disrupting type I interferon response and subsequent suppression of expression of Interferon stimulatory genes (ISGs). Viperin, a member of ISGs, is considered as a host antiviral protein, which interferes with viral replication. Since it is a good target for some viruses to evade host responses, it is interesting to study if HCV has evolved a mechanism to interfere with this member of ISGs.Materials and Methods: We evaluated the impact of NS3, NS3/4A and a mutated nonfunctional NS3 on ISGs expression such as viperin and IL-28 after the induction of IFN signaling Jak-STAT pathway using IFN-.Results: NS3 protein disrupted the expressions of viperin gene and IL-28, an inducer for the expression of ISGs and viperin itself. By comparing the roles of NS3 and NS3/4A protease activities in suppressing the innate immune responses, we also showed that NS3 (without NS4A) has the ability to down-regulate ISGs expression, similar to that of NS3/4A.Conclusions: ISGs expression is impeded by NS3 protease activity and its interaction with Jak-STAT pathway proteins. In addition, the NS3/4A substrates spectrum seems to be similar to those of NS3.

Cites

EXPRESSION OF NS3/NS4A PROTEINS OF HEPATITIS C VIRUS IN HUH7 CELLS FOLLOWING ENGINEERING ITS EUKARYOTIC EXPRESSION VECTOR

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APA: Copy

KHANLARI, ZAHRA, SABAHI, FARZANEH, HOSSEINI, SEYED YOUNES, & GHADERI, MOSTAFA. (2014). HCV NS3 BLOCKING EFFECT ON IFN INDUCED ISGS LIKE VIPERIN AND IL28 WITH AND WITHOUT NS4A. HEPATITIS MONTHLY, 14(6), 0-0. SID. https://sid.ir/paper/306642/en

Vancouver: Copy

KHANLARI ZAHRA, SABAHI FARZANEH, HOSSEINI SEYED YOUNES, GHADERI MOSTAFA. HCV NS3 BLOCKING EFFECT ON IFN INDUCED ISGS LIKE VIPERIN AND IL28 WITH AND WITHOUT NS4A. HEPATITIS MONTHLY[Internet]. 2014;14(6):0-0. Available from: https://sid.ir/paper/306642/en

IEEE: Copy

ZAHRA KHANLARI, FARZANEH SABAHI, SEYED YOUNES HOSSEINI, and MOSTAFA GHADERI, “HCV NS3 BLOCKING EFFECT ON IFN INDUCED ISGS LIKE VIPERIN AND IL28 WITH AND WITHOUT NS4A,” HEPATITIS MONTHLY, vol. 14, no. 6, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/306642/en

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