TYPE II AUTOIMMUNE HEPATITIS AND SMALL DUCT SCLEROSING CHOLANGITIS IN A SEVEN YEARS OLD CHILD: AN OVERLAP SYNDROME?

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PRATICO ANDREA DOMENICO; SALAFIA STEFANIA; BARONE PATRIZIA; ROSA MARIO LA; LEONARDI SALVATORE

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Journal: Hepatitis Monthly Year:2013 | Volume:13 | Issue:12 Page(s): 1-3

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Title

TYPE II AUTOIMMUNE HEPATITIS AND SMALL DUCT SCLEROSING CHOLANGITIS IN A SEVEN YEARS OLD CHILD: AN OVERLAP SYNDROME?

Author(s)

Keywords

HEPATITIS

AUTOIMMUNE

PRIMARY SCLEROSING CHOLANGITIS

LIVER DISEASES

ANTI-LIVER KIDNEY MICROSOME ANTIBODY

Abstract

Introduction: AUTOIMMUNE HEPATITIS is an inflammatory disease with multifactorial ethiopatogenesis, characterized by lympho-monocytic infiltration of liver, presence of serum autoantibodies (ANA, SMA, LKM-1) and high levels of immunoglobulins. Overlap syndromes are defined as the association of AUTOIMMUNE HEPATITIS with cholestatic diseases such as primary biliary cirrhosis and PRIMARY SCLEROSING CHOLANGITIS. The boundaries of these syndromes as distinct pathological entities are still matter of debate and they could be part of a major liver AUTOIMMUNE disease. Furthermore, cholestatic diseases may present even with atypical features (AMA-negative primary cirrohosis, PRIMARY SCLEROSING CHOLANGITIS with normal cholangiography).Case Presentation: We herein describe a case of a 7 year-old child affected by an overlap syndrome between type 2 AUTOIMMUNE HEPATITIS and small duct PRIMARY SCLEROSING CHOLANGITIS. Although characterized by a severe onset, the disease showed a good response to treatment with prednisone and azathioprine.Conclusions: The association of type 2 AUTOIMMUNE HEPATITIS and small duct primary cholangitis has been rarely reported in literature and this report adds new data on this still unclear entity.

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APA: Copy

PRATICO, ANDREA DOMENICO, SALAFIA, STEFANIA, BARONE, PATRIZIA, ROSA, MARIO LA, & LEONARDI, SALVATORE. (2013). TYPE II AUTOIMMUNE HEPATITIS AND SMALL DUCT SCLEROSING CHOLANGITIS IN A SEVEN YEARS OLD CHILD: AN OVERLAP SYNDROME?. HEPATITIS MONTHLY, 13(12), 1-3. SID. https://sid.ir/paper/306715/en

Vancouver: Copy

PRATICO ANDREA DOMENICO, SALAFIA STEFANIA, BARONE PATRIZIA, ROSA MARIO LA, LEONARDI SALVATORE. TYPE II AUTOIMMUNE HEPATITIS AND SMALL DUCT SCLEROSING CHOLANGITIS IN A SEVEN YEARS OLD CHILD: AN OVERLAP SYNDROME?. HEPATITIS MONTHLY[Internet]. 2013;13(12):1-3. Available from: https://sid.ir/paper/306715/en

IEEE: Copy

ANDREA DOMENICO PRATICO, STEFANIA SALAFIA, PATRIZIA BARONE, MARIO LA ROSA, and SALVATORE LEONARDI, “TYPE II AUTOIMMUNE HEPATITIS AND SMALL DUCT SCLEROSING CHOLANGITIS IN A SEVEN YEARS OLD CHILD: AN OVERLAP SYNDROME?,” HEPATITIS MONTHLY, vol. 13, no. 12, pp. 1–3, 2013, [Online]. Available: https://sid.ir/paper/306715/en

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