IS THERE ANY DIFFERENCE BETWEEN THE GLOMERULAR FILTRATION RATE OF PATIENTS WITH CHRONIC HEPATITIS B AND C AND PATIENTS WITH CIRRHOSIS?

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GLUHOVSCHI CRISTINA; VELCIOV SILVIA; BUZAS ROXANA; PETRICA LIGIA; BOZDOG GHEORGHE; GADALEAN FLORICA; GLUHOVSCHI ADRIAN; BALGRADEAN CRISTIAN; VERNIC CORINA; SPOREA IOAN

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Journal: Hepatitis Monthly Year:2013 | Volume:13 | Issue:4 Page(s): 1-5

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Title

IS THERE ANY DIFFERENCE BETWEEN THE GLOMERULAR FILTRATION RATE OF PATIENTS WITH CHRONIC HEPATITIS B AND C AND PATIENTS WITH CIRRHOSIS?

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Keywords

HEPATITIS B VIRUS

HEPATITIS C

LIVER CIRRHOSIS

GLOMERULAR FILTRATION RATE

Abstract

Background: Renal dysfunction is a major determinant of the Model of End-stage Liver Disease (MELD) score. The implementation of the MELD score has shifted allocation of livers to patients with renal dysfunction.Objectives: The aim of our study was the assessment of estimated GLOMERULAR FILTRATION RATE (eGFR) by the Modification of Diet in Renal Disease 4 (MDRD4) method in patients with HBV chronic hepatitis, HCV chronic hepatitis, and cirrhosis (CH) caused by these viruses to detect any differences in renal function among these diseases.Patients and Methods: We performed a cross-sectional analysis of all consecutive patients with HBV chronic hepatitis, HCV chronic hepatitis, and cirrhosis caused by these viruses hospitalized during a 4 year period in the Gastroenterology and Hepatology department of the Emergency County Hospital Timisoara, Romania. The eGFR was assessed by the MDRD4 method. Statistical analysis (unpaired t-test, ANOVA, Chi Square test) was performed using OpenEpi 2.3.1.Results: HBV chronic hepatitis, HCV chronic hepatitis, and cirrhosis secondary to these viruses were associated with a reduction of the GFR. The eGFR was higher in patients with HBV chronic hepatitis than in patients with HCV chronic hepatitis (P<0.001). Patients with cirrhosis secondary to HBV infection had a higher eGFR than patients with cirrhosis secondary to HCV (P=0.01). The eGFR of patients with HCV chronic hepatitis was higher than the eGFR of patients with cirrhosis due to this virus (P<0.001).Conclusions: Functional renal impairment in diseases caused by HCV was more important than in diseases caused by HBV. The eGFR was statistically lower in cirrhosis secondary to HCV than in HCV chronic hepatitis.

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APA: Copy

GLUHOVSCHI, CRISTINA, VELCIOV, SILVIA, BUZAS, ROXANA, PETRICA, LIGIA, BOZDOG, GHEORGHE, GADALEAN, FLORICA, GLUHOVSCHI, ADRIAN, BALGRADEAN, CRISTIAN, VERNIC, CORINA, & SPOREA, IOAN. (2013). IS THERE ANY DIFFERENCE BETWEEN THE GLOMERULAR FILTRATION RATE OF PATIENTS WITH CHRONIC HEPATITIS B AND C AND PATIENTS WITH CIRRHOSIS?. HEPATITIS MONTHLY, 13(4), 1-5. SID. https://sid.ir/paper/306741/en

Vancouver: Copy

GLUHOVSCHI CRISTINA, VELCIOV SILVIA, BUZAS ROXANA, PETRICA LIGIA, BOZDOG GHEORGHE, GADALEAN FLORICA, GLUHOVSCHI ADRIAN, BALGRADEAN CRISTIAN, VERNIC CORINA, SPOREA IOAN. IS THERE ANY DIFFERENCE BETWEEN THE GLOMERULAR FILTRATION RATE OF PATIENTS WITH CHRONIC HEPATITIS B AND C AND PATIENTS WITH CIRRHOSIS?. HEPATITIS MONTHLY[Internet]. 2013;13(4):1-5. Available from: https://sid.ir/paper/306741/en

IEEE: Copy

CRISTINA GLUHOVSCHI, SILVIA VELCIOV, ROXANA BUZAS, LIGIA PETRICA, GHEORGHE BOZDOG, FLORICA GADALEAN, ADRIAN GLUHOVSCHI, CRISTIAN BALGRADEAN, CORINA VERNIC, and IOAN SPOREA, “IS THERE ANY DIFFERENCE BETWEEN THE GLOMERULAR FILTRATION RATE OF PATIENTS WITH CHRONIC HEPATITIS B AND C AND PATIENTS WITH CIRRHOSIS?,” HEPATITIS MONTHLY, vol. 13, no. 4, pp. 1–5, 2013, [Online]. Available: https://sid.ir/paper/306741/en

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