VIROLOGICAL RESPONSE AND MUSCULAR ADVERSE EVENTS DURING LONG-TERM CLEVUDINE THERAPY IN CHRONIC HEPATITIS B PATIENTS

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KIM BYUNG KOOK; KO SOON YOUNG; KWON SO YOUNG; PARK EUGENE; KIM JEONG HAN; CHOE WON HYEOK; LEE CHANG HONG

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Journal: Hepatitis Monthly Year:2013 | Volume:13 | Issue:4 Page(s): 1-9

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Title

VIROLOGICAL RESPONSE AND MUSCULAR ADVERSE EVENTS DURING LONG-TERM CLEVUDINE THERAPY IN CHRONIC HEPATITIS B PATIENTS

Author(s)

Keywords

HEPATITIS B

CHRONIC

2’-FLUORO-5-METHYLARABINOSYLURACIL

RESPONSE ELEMENTS

ADVERSE EFFECT

HEPATITIS B

CHRONIC

2’-FLUORO-5-METHYLARABINOSYLURACIL

RESPONSE ELEMENTS

ADVERSE EFFECT

Abstract

Background: Recently, several reports issued clevudine induced myopathy in the long term use.Objectives: The aim of this study was to investigate antiviral effects and adverse events of clevudine monotherapy in patients with CHRONIC HEPATITIS B (CHB).Patients and Methods: The subjects were 110 treatment-naïve CHB patients. They were treated with 30 mg clevudine/day for more than six months. Virological and biochemical tests, including that for serum creatine kinase (CK), were monitored at baseline and at 3-month intervals during treatment period.Results: In HBeAg-positive patients, the cumulative rates of virological response were 74.0 %, 68.5 %, and 67.3 % after one, two, and three years of clevudine treatment, respectively. Cumulative rates of HBeAg loss or seroconversion were 17.8 %, 30 %, and 31.5 % after one, two and, three years of clevudine treatment, respectively. In HBeAg-negative patients, the cumulative rates of virological response were 97.3 %, 100 %, and 94.6 %, respectively. Virological breakthrough occurred in 27 patients. The rtM204I mutation in HBV polymerase was predominantly detected. Muscular adverse events were observed in 15 patients. All patients with myopathy recovered after the cessation of clevudine monotherapy. Fluctuations in CK level during the clevudine treatment period were frequently observed irrespective of development of myopathy. Multiple episodes of CK elevation were significantly related to the development of myopathy.Conclusions: Long-term clevudine monotherapy is effective for suppression of serum HBV DNA level and normalization of serum alanine amino transaminase levels, but associated with occurrence of rtM204I mutation. Clevudine-induced muscular adverse events are not uncommon, although they are totally reversible after cessation of the treatment. Muscular adverse events and serum CK level should be carefully monitored during long-term treatment with clevudine.

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APA: Copy

KIM, BYUNG KOOK, KO, SOON YOUNG, KWON, SO YOUNG, PARK, EUGENE, KIM, JEONG HAN, CHOE, WON HYEOK, & LEE, CHANG HONG. (2013). VIROLOGICAL RESPONSE AND MUSCULAR ADVERSE EVENTS DURING LONG-TERM CLEVUDINE THERAPY IN CHRONIC HEPATITIS B PATIENTS. HEPATITIS MONTHLY, 13(4), 1-9. SID. https://sid.ir/paper/306749/en

Vancouver: Copy

KIM BYUNG KOOK, KO SOON YOUNG, KWON SO YOUNG, PARK EUGENE, KIM JEONG HAN, CHOE WON HYEOK, LEE CHANG HONG. VIROLOGICAL RESPONSE AND MUSCULAR ADVERSE EVENTS DURING LONG-TERM CLEVUDINE THERAPY IN CHRONIC HEPATITIS B PATIENTS. HEPATITIS MONTHLY[Internet]. 2013;13(4):1-9. Available from: https://sid.ir/paper/306749/en

IEEE: Copy

BYUNG KOOK KIM, SOON YOUNG KO, SO YOUNG KWON, EUGENE PARK, JEONG HAN KIM, WON HYEOK CHOE, and CHANG HONG LEE, “VIROLOGICAL RESPONSE AND MUSCULAR ADVERSE EVENTS DURING LONG-TERM CLEVUDINE THERAPY IN CHRONIC HEPATITIS B PATIENTS,” HEPATITIS MONTHLY, vol. 13, no. 4, pp. 1–9, 2013, [Online]. Available: https://sid.ir/paper/306749/en

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