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Title

CORRELATION BETWEEN VIRAL LOAD OF HBV IN CHRONIC HEPATITIS B PATIENTS AND PRECORE AND BASAL CORE PROMOTER MUTATIONS

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Abstract

 Background: More than two billion people have been exposed to HEPATITIS B VIRUS (HBV) worldwide. Furthermore, four hundred million of them are infected with chronic HBV infection. The predominant mutation of the precore region involves a G to A change at nucleotide1896, which creates a premature stop codon at codon 28. Two MUTATIONS of A1762T and G1764A are reported as the most prevalent MUTATIONS in the basal core promoter (BCP).Objectives: The purpose of this study was to investigate the relationship between MUTATIONS in precore (PC) and basal core promoter regions, and the VIRAL LOAD.Patients and Methods: Fifty serum samples from patients with hepatitis B were used. Levels of liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured at the same time of serological markers of hepatitis B by ELISA. HBV-DNA was extracted from the sera, and then PCR performed on the HBV-DNA extracted with the use of specific primer of gene C. HBV VIRAL LOAD was determined by real-time PCR. The PC/ BCP MUTATIONS were determined by applying Line Probe Assay technique. The data were analyzed using SPSS software, version 20.Results: Only 82% of the patients were HBeAb positive and 76% of the patients had basal core/ precore MUTATIONS and mean VIRAL LOAD was 3/7 ¡Á 106 ¡À 9/7 ¡Á 105 IU/ml. Prevalence of MUTATIONS in the precore and basal core promoter regions were 46% and 30%, respectively. Conclusions: Our data indicated that there is a statistically significant relationship between HBV VIRAL LOAD and MUTATIONS in precore region (P<0.05).

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    APA: Copy

    GHABESHI, SOAD, SHARIFI, ZOHREH, HOSSEINI, SEYED MASOUD, & MAHMOODIAN SHOOSHTARI, MAHMOOD. (2013). CORRELATION BETWEEN VIRAL LOAD OF HBV IN CHRONIC HEPATITIS B PATIENTS AND PRECORE AND BASAL CORE PROMOTER MUTATIONS. HEPATITIS MONTHLY, 13(2), 0-0. SID. https://sid.ir/paper/306751/en

    Vancouver: Copy

    GHABESHI SOAD, SHARIFI ZOHREH, HOSSEINI SEYED MASOUD, MAHMOODIAN SHOOSHTARI MAHMOOD. CORRELATION BETWEEN VIRAL LOAD OF HBV IN CHRONIC HEPATITIS B PATIENTS AND PRECORE AND BASAL CORE PROMOTER MUTATIONS. HEPATITIS MONTHLY[Internet]. 2013;13(2):0-0. Available from: https://sid.ir/paper/306751/en

    IEEE: Copy

    SOAD GHABESHI, ZOHREH SHARIFI, SEYED MASOUD HOSSEINI, and MAHMOOD MAHMOODIAN SHOOSHTARI, “CORRELATION BETWEEN VIRAL LOAD OF HBV IN CHRONIC HEPATITIS B PATIENTS AND PRECORE AND BASAL CORE PROMOTER MUTATIONS,” HEPATITIS MONTHLY, vol. 13, no. 2, pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/306751/en

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