DISTRIBUTION OF IL28B GENOTYPES IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS C AND HEALTHY INDIVIDUALS

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SHARAFI HEIDAR; POURYASIN ALI; ALAVIAN SEYED MOAYED; BEHNAVA BITA; KESHVARI MARYAM; SALIMI SHIMA; MEHRNOUSH LEILA; FATEMI AHMAD

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Journal: Hepatitis Monthly Year:2012 | Volume:12 | Issue:12 Page(s): 0-0

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Title

DISTRIBUTION OF IL28B GENOTYPES IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS C AND HEALTHY INDIVIDUALS

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Keywords

POLYMORPHISM

GENETIC

HEPATITIS C

IL28B GENOTYPE

HUMAN

PERSIAN GULF

IRAN

Abstract

Background: IL28B POLYMORPHISM is recognized as one of the most prominent predictors of HEPATITIS C spontaneous and treatment-induced clearance. Interestingly, the favorable genotypes of IL28B are found to be more frequent in Asian ethnicity than Caucasian and African populations, respectively. A few studies reported that there is a mysterious association between the IL28B POLYMORPHISM and the HEPATITIS C virus (HCV) genotype in patients with chronic HEPATITIS C but they did not give any reason for this phenomenon. Objectives: The foremost purpose of this study was to compare the distribution of IL28B GENOTYPEs between IRANian healthy individuals and patients with chronic HEPATITIS C.Patients and Methods: In this study, 921 patients with chronic HEPATITIS C and 142 healthy individuals were included. The IL28B rs12979860 and rs8099917 POLYMORPHISMs were genotyped using the polymerase chain reaction-restriction fragment length POLYMORPHISM (PCR-RFLP) method.Results: The frequency of IL28B rs12979860 CC, CT, and TT genotypes in chronic HEPATITIS C patients was 38%, 48.8%, and 13.2% and in healthy individuals was 43.7%, 48.6%, and 7.7%. Also, the frequency of IL28B rs8099917 TT, GT, and GG genotypes in chronic HEPATITIS C patients was 58.3%, 37.1%, and 4.6% and in healthy individuals was 64.1%, 32.4% and 3.5%. The differences in the distribution of IL28B rs12979860 and rs8099917 genotypes between patients with chronic HEPATITIS C and healthy individuals were not statistically significant. When we compared the distribution of IL28B GENOTYPEs between the healthy group and the HCV infected patients by HCV genotype, we found 9.8% higher frequency of rs12979860 CC genotype in the healthy individuals than HCV genotype 1 infected patients (P=0.03) however there was no significant difference in the distribution of rs12979860 genotypes between the healthy and HCV genotype 3 infected groups (P=0.46). Conclusions: It seems that the impact of IL28B POLYMORPHISM on the spontaneous clearance of HCV genotype 1 is more prominent than HCV genotype 3 which results in the observation of higher rs12979860 C allele frequency in chronic HEPATITIS C patients with HCV genotype 3 than HCV genotype 1.

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APA: Copy

SHARAFI, HEIDAR, POURYASIN, ALI, ALAVIAN, SEYED MOAYED, BEHNAVA, BITA, KESHVARI, MARYAM, SALIMI, SHIMA, MEHRNOUSH, LEILA, & FATEMI, AHMAD. (2012). DISTRIBUTION OF IL28B GENOTYPES IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS C AND HEALTHY INDIVIDUALS. HEPATITIS MONTHLY, 12(12), 0-0. SID. https://sid.ir/paper/306764/en

Vancouver: Copy

SHARAFI HEIDAR, POURYASIN ALI, ALAVIAN SEYED MOAYED, BEHNAVA BITA, KESHVARI MARYAM, SALIMI SHIMA, MEHRNOUSH LEILA, FATEMI AHMAD. DISTRIBUTION OF IL28B GENOTYPES IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS C AND HEALTHY INDIVIDUALS. HEPATITIS MONTHLY[Internet]. 2012;12(12):0-0. Available from: https://sid.ir/paper/306764/en

IEEE: Copy

HEIDAR SHARAFI, ALI POURYASIN, SEYED MOAYED ALAVIAN, BITA BEHNAVA, MARYAM KESHVARI, SHIMA SALIMI, LEILA MEHRNOUSH, and AHMAD FATEMI, “DISTRIBUTION OF IL28B GENOTYPES IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS C AND HEALTHY INDIVIDUALS,” HEPATITIS MONTHLY, vol. 12, no. 12, pp. 0–0, 2012, [Online]. Available: https://sid.ir/paper/306764/en

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