NON-INVASIVE PREDICTION OF HEPATIC FIBROSIS IN PATIENTS WITH CHRONIC HCV BASED ON THE ROUTINE PRE-TREATMENT WORKUP

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KHAIRY MARWA; ABDEL RAHMAN MAHASSEN; EL RAZIKY MAISSA; EL AKEL WAFAA; ZAYED NAGLAA; KHATAB HANY; ESMAT GAMAL

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Journal: Hepatitis Monthly Year:2012 | Volume:12 | Issue:11 Page(s): 0-0

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Title

NON-INVASIVE PREDICTION OF HEPATIC FIBROSIS IN PATIENTS WITH CHRONIC HCV BASED ON THE ROUTINE PRE-TREATMENT WORKUP

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Keywords

HEPATITIS C

LIVER CIRRHOSIS

FIBROSIS

Abstract

Background: Hepatic FIBROSIS is an inclusion indicator for treatment and a major independent predictor of treatment response in patients with chronic HEPATITIS C. Liver biopsy, considered as the “gold standard” for evaluating liver FIBROSIS, has carried some drawbacks. Currently used noninvasive predictors of FIBROSIS are considered less accurate than liver biopsy.Objectives: Our aim was to assess noninvasive predictors of FIBROSIS in patients with chronic HEPATITIS C using the routine laboratory pre-treatment workup.Patients and Methods: Cross sectional study including 4289 Egyptian patients with chronic HEPATITIS C were assessed for the need to interferon and ribavirin therapy. Routine pre-treatment workup and reference needle liver biopsy were performed. FIB-4 index, APRI and modified APRI scores were validated. Patients were divided into two groups, first with no or minimal FIBROSIS, and second with moderate and marked FIBROSIS using the Metavir score.Results: Multivariate logistic regression analysis showed that age, body mass index, aspartate aminotransferase, alpha fetoprotein, platelets count, FIB-4 index, APRI and modified APRI score were significant independent predictors of FIBROSIS. Age >43 years, aspartate aminotransferase > 47U/L, platelets < 205×103/mm3, and alpha fetoprotein >2.6 ng/ml had the highest cutoff points in receiver operator characteristic curves. Taking into account the four variables together; the presence of ≥2 variables is associated with moderate and advanced FIBROSIS with a sensitivity of 0.81, specificity of 0.5, positive predictive value of 0.53 and negative predictive value of 0.79. FIB-4 index represented the best performing receiver operator characteristic curve for diagnosing moderate and marked FIBROSIS among other independent factors with a sensitivity of 0.74, specificity of 0.6, positive predictive value of 0.56 and negative predictive value of 0.76.Conclusions: Chronic HCV pre-treatment routine work up and composite FIBROSIS scores are good noninvasive predictor of liver FIBROSIS and can be used as an alternative method to invasive liver biopsy without adding more financial expenses to the treatment.

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APA: Copy

KHAIRY, MARWA, ABDEL RAHMAN, MAHASSEN, EL RAZIKY, MAISSA, EL AKEL, WAFAA, ZAYED, NAGLAA, KHATAB, HANY, & ESMAT, GAMAL. (2012). NON-INVASIVE PREDICTION OF HEPATIC FIBROSIS IN PATIENTS WITH CHRONIC HCV BASED ON THE ROUTINE PRE-TREATMENT WORKUP. HEPATITIS MONTHLY, 12(11), 0-0. SID. https://sid.ir/paper/306779/en

Vancouver: Copy

KHAIRY MARWA, ABDEL RAHMAN MAHASSEN, EL RAZIKY MAISSA, EL AKEL WAFAA, ZAYED NAGLAA, KHATAB HANY, ESMAT GAMAL. NON-INVASIVE PREDICTION OF HEPATIC FIBROSIS IN PATIENTS WITH CHRONIC HCV BASED ON THE ROUTINE PRE-TREATMENT WORKUP. HEPATITIS MONTHLY[Internet]. 2012;12(11):0-0. Available from: https://sid.ir/paper/306779/en

IEEE: Copy

MARWA KHAIRY, MAHASSEN ABDEL RAHMAN, MAISSA EL RAZIKY, WAFAA EL AKEL, NAGLAA ZAYED, HANY KHATAB, and GAMAL ESMAT, “NON-INVASIVE PREDICTION OF HEPATIC FIBROSIS IN PATIENTS WITH CHRONIC HCV BASED ON THE ROUTINE PRE-TREATMENT WORKUP,” HEPATITIS MONTHLY, vol. 12, no. 11, pp. 0–0, 2012, [Online]. Available: https://sid.ir/paper/306779/en

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