TREATMENT RESPONSE AND TOLERABILITY OF PEGYLATED INTERFERON-α PLUS RIBAVIRIN COMBINATION THERAPY IN ELDERLY PATIENTS (≥65 YEARS) WITH CHRONIC HEPATITIS C IN KOREA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KIM HYEONG IL; KIM IN HEE; JEON BYUNG JUN; LEE SEOK; KIM SEONG HUN; KIM SANG WOOK; LEE SEUNG OK; LEE SOO TEIK; KIM DAE GHON

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Hepatitis Monthly Year:2012 | Volume:12 | Issue:7 Page(s): 430-436

Download Full-Text

View:

327

Download:

366

Cites:

Information Journal Paper

Title

TREATMENT RESPONSE AND TOLERABILITY OF PEGYLATED INTERFERON-α PLUS RIBAVIRIN COMBINATION THERAPY IN ELDERLY PATIENTS (≥65 YEARS) WITH CHRONIC HEPATITIS C IN KOREA

Author(s)

Keywords

CHRONIC HEPATITIS C

RIBAVIRIN

KOREA

Abstract

Background: The prevalence of hepatitis C virus (HCV) infections in elderly patients has been increasing in a number of countries. A few reports concerning pegylated interferon-a (PEG-IFN-a) -based combination treatment in elderly CHRONIC HEPATITIS C (CHC) patients have been published, with slightly different treatment outcomes.Objectives: We investigated the treatment response and safety of PEG-IFN-a plus RIBAVIRIN combination therapy in elderly patients with CHC.Patients and Methods: Among a total of 181 treatment-naive CHC patients (60 patients with genotype 1, 121 patients with genotype 2 or 3), 38 were aged ³65 years (defined as the elderly group) and 143 were aged<65 years (defined as the non-elderly group).Results: The overall sustained virologic response (SVR) was lower in the elderly group than in the non-elderly group, but it was not significantly different (65.8%vs.76.2%, P=0.15). In a subgroup analysis, among patients with genotype 1, the elderly group had a significantly lower SVR rate than the non-elderly group (30.8%vs.66.0%, P=0.03). However, the SVR rate in patients with HCV genotype 2 or 3 was comparable between the two groups (84.0%vs. 81.3%, P=0.85). HCV genotype was significantly associated with SVR in the elderly patients (genotype 1vs.2 or 3, odds ratio: 0.18, 95% confidence interval: 0.000-0.869, P=0.03). The incidence of premature discontinuation of treatment (21.1%vs.9.1%, P=0.05) and dose modification (52.6%vs.31.5%; P=0.02) due mainly to adverse events or laboratory abnormalities, were higher in the elderly group than in the non-elderly group.Conclusions: PEG-IFN-a plus RIBAVIRIN combination therapy might be considered for elderly CHC patients, especially for genotype 2 or 3, with vigilant monitoring of adverse events.

Cites

No record.

References

No record.

Cite

APA: Copy

KIM, HYEONG IL, KIM, IN HEE, JEON, BYUNG JUN, LEE, SEOK, KIM, SEONG HUN, KIM, SANG WOOK, LEE, SEUNG OK, LEE, SOO TEIK, & KIM, DAE GHON. (2012). TREATMENT RESPONSE AND TOLERABILITY OF PEGYLATED INTERFERON-α PLUS RIBAVIRIN COMBINATION THERAPY IN ELDERLY PATIENTS (≥65 YEARS) WITH CHRONIC HEPATITIS C IN KOREA. HEPATITIS MONTHLY, 12(7), 430-436. SID. https://sid.ir/paper/306793/en

Vancouver: Copy

KIM HYEONG IL, KIM IN HEE, JEON BYUNG JUN, LEE SEOK, KIM SEONG HUN, KIM SANG WOOK, LEE SEUNG OK, LEE SOO TEIK, KIM DAE GHON. TREATMENT RESPONSE AND TOLERABILITY OF PEGYLATED INTERFERON-α PLUS RIBAVIRIN COMBINATION THERAPY IN ELDERLY PATIENTS (≥65 YEARS) WITH CHRONIC HEPATITIS C IN KOREA. HEPATITIS MONTHLY[Internet]. 2012;12(7):430-436. Available from: https://sid.ir/paper/306793/en

IEEE: Copy

HYEONG IL KIM, IN HEE KIM, BYUNG JUN JEON, SEOK LEE, SEONG HUN KIM, SANG WOOK KIM, SEUNG OK LEE, SOO TEIK LEE, and DAE GHON KIM, “TREATMENT RESPONSE AND TOLERABILITY OF PEGYLATED INTERFERON-α PLUS RIBAVIRIN COMBINATION THERAPY IN ELDERLY PATIENTS (≥65 YEARS) WITH CHRONIC HEPATITIS C IN KOREA,” HEPATITIS MONTHLY, vol. 12, no. 7, pp. 430–436, 2012, [Online]. Available: https://sid.ir/paper/306793/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops