EFFECTS OF ANTIVIRAL THERAPY ON THE RECURRENCE OF HEPATOCELLULAR CARCINOMA AFTER CURATIVE RESECTION OR LIVER TRANSPLANTATION

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DU YAN; SU TONG; DING YIBO; CAO GUANGWEN

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Journal: Hepatitis Monthly Year:2012 | Volume:12 | Issue:10 Page(s): 0-0

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Title

EFFECTS OF ANTIVIRAL THERAPY ON THE RECURRENCE OF HEPATOCELLULAR CARCINOMA AFTER CURATIVE RESECTION OR LIVER TRANSPLANTATION

Author(s)

DU YAN | SU TONG | DING YIBO | CAO GUANGWEN | Issue Writer Certificate

Keywords

CARCINOMA

HEPATOCELLULAR

SURGICAL PROCEDURES

OPERATIVE

RECURRENCE

SURVIVAL

Abstract

Context: HEPATOCELLULAR CARCINOMA (HCC) is a fatal disease. Chronic hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infection is the major cause of HCC. High viral replication rate and related hepatic/systematic inflammation are the major risk factors in HCC RECURRENCE after hepatectomy or liver transplantation.Evidence Acquisition: Some of the carcinogenesis-related HBV mutations are also associated with poor prognosis for HCC patients. Antiviral therapy is an option for improving HCC prognosis after surgery. In case of HBV-associated HCC, treatment with interferon and nucleos (t) ide analogues (NAs), especially interferon, is effective in improving the prognosis. However, long-term use of NAs increases the possibility of developing drug-resistant viral mutations such as the HBV rtA181T/sW172 mutation, which increases the risk of HCC RECURRENCE.Results: In cases of HCV-associated HCC, standard interferon with or without ribavirin therapy is effective in improving the prognosis of HCV-associated HCC; however, some HCV mutations, such as the amino acid substitution M91L, are associated with treatment failure and a poor prognosis. Therapeutic efficacy needs to be confirmed using largescale, randomized, placebo-controlled clinical trials.Conclusions: Surveillance of viral mutations during antiviral treatment and a better understanding of the associations of HCC RECURRENCE with viral load, inflammation-associated signaling, and environmental factors can aid the development of more effective strategies for the prevention of HCC RECURRENCE after surgery.

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APA: Copy

DU, YAN, SU, TONG, DING, YIBO, & CAO, GUANGWEN. (2012). EFFECTS OF ANTIVIRAL THERAPY ON THE RECURRENCE OF HEPATOCELLULAR CARCINOMA AFTER CURATIVE RESECTION OR LIVER TRANSPLANTATION. HEPATITIS MONTHLY, 12(10), 0-0. SID. https://sid.ir/paper/306809/en

Vancouver: Copy

DU YAN, SU TONG, DING YIBO, CAO GUANGWEN. EFFECTS OF ANTIVIRAL THERAPY ON THE RECURRENCE OF HEPATOCELLULAR CARCINOMA AFTER CURATIVE RESECTION OR LIVER TRANSPLANTATION. HEPATITIS MONTHLY[Internet]. 2012;12(10):0-0. Available from: https://sid.ir/paper/306809/en

IEEE: Copy

YAN DU, TONG SU, YIBO DING, and GUANGWEN CAO, “EFFECTS OF ANTIVIRAL THERAPY ON THE RECURRENCE OF HEPATOCELLULAR CARCINOMA AFTER CURATIVE RESECTION OR LIVER TRANSPLANTATION,” HEPATITIS MONTHLY, vol. 12, no. 10, pp. 0–0, 2012, [Online]. Available: https://sid.ir/paper/306809/en

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