مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

373
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

209
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

CLINICAL VALUES OF ELEVATED SERUM CYTOKERATIN-18 LEVELS IN HEPATITIS: A META-ANALYSIS

Pages

  0-0

Abstract

 Background: As an important intermediate filament protein within liver cells, CYTOKERATIN-18 (CK-18) has been confirmed as a potential indicator in various HEPATITIS progressions.Objectives: We sought to clarify the connection between serum CK-18 levels and HEPATITIS pathogenesis in the present META-ANALYSIS.Materials and Methods: With the application of various computerized databases, including PubMed, Embase, Cochrane Library, Google Scholar, Web of Science, China BioMedicine (CBM), China National Knowledge Infrastructure (CNKI), published papers that assessed the relationship between serum CK-18 levels and HEPATITIS were obtained. The main key words used are “Hepatitis”, “hepatitides”, “CYTOKERATIN-18”, “Keratin-18” and “CK-18”. Statistical analysis was conducted using the STATA software (version 12.0).Results: Eight case-control studies published between 2010 and 2014 were confirmed eligible, according to our selection criteria. The results of the META-ANALYSIS showed that serum levels of CK-18 in HEPATITIS patients were higher compared to healthy controls (standardized mean difference (SMD) = 3.71, 95%CI: 2.27-5.14, P<0.001). Subgroup analysis by ethnicity and disease implicated that high serum CK-18 levels might be a risk factor for non-alcoholic steatohepatitis (NASH), chronic HEPATITIS C (CHC), and chronic HEPATITIS B (CHB) (all P<0.05) among Asians (SMD=2.89, 95%CI: 2.35-3.43, P<0.001), Africans (SMD=0.69, 95%CI: 0.12-1.26, P=0.017), and Caucasians (SMD=4.86, 95%CI: 1.82-7.89, P=0.002).Conclusions: Serum CK-18 levels in HEPATITIS patients were higher, compared with healthy controls. Our results revealed the clinical values of CK-18, in combination with other apoptosis markers, in identifying the development of HEPATITIS.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    YANG, ZHAO HUI, YANG, SU XIAN, QIN, CHENG ZHI, & CHEN, YUN XIU. (2015). CLINICAL VALUES OF ELEVATED SERUM CYTOKERATIN-18 LEVELS IN HEPATITIS: A META-ANALYSIS. HEPATITIS MONTHLY, 15(5), 0-0. SID. https://sid.ir/paper/306871/en

    Vancouver: Copy

    YANG ZHAO HUI, YANG SU XIAN, QIN CHENG ZHI, CHEN YUN XIU. CLINICAL VALUES OF ELEVATED SERUM CYTOKERATIN-18 LEVELS IN HEPATITIS: A META-ANALYSIS. HEPATITIS MONTHLY[Internet]. 2015;15(5):0-0. Available from: https://sid.ir/paper/306871/en

    IEEE: Copy

    ZHAO HUI YANG, SU XIAN YANG, CHENG ZHI QIN, and YUN XIU CHEN, “CLINICAL VALUES OF ELEVATED SERUM CYTOKERATIN-18 LEVELS IN HEPATITIS: A META-ANALYSIS,” HEPATITIS MONTHLY, vol. 15, no. 5, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306871/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button