LRRFIP1 INHIBITS HEPATITIS C VIRUS REPLICATION BY INDUCING TYPE I INTERFERON IN HEPATOCYTES

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LIU YUAN; ZOU ZIYING; ZHU BING; HU ZONGHAI; ZENG PING; WU LIJUAN

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Journal: Hepatitis Monthly Year:2015 | Volume:15 | Issue:5 Page(s): 0-0

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Title

LRRFIP1 INHIBITS HEPATITIS C VIRUS REPLICATION BY INDUCING TYPE I INTERFERON IN HEPATOCYTES

Author(s)

Keywords

LRRFIP1 PROTEIN

HUMAN

HEPACIVIRUS

INTERFERON TYPE I

Abstract

Background: Hepatitis C virus infection is one of the leading causes of end stage liver diseases. The innate immune response slows down viral replication by activating cytokines such as type I interferon (IFN-a/ b), which trigger the synthesis of antiviral proteins and modulate the adaptive immune system. Recently, leucine-rich repeat (in Flightless I) interacting protein-1 (LRRFIP1) was reported contributing to the production of interferon- b in macrophages.Objectives: The aim of this study was to assess the role of LRRFIP1 in induction of IFN- b and inhibition of HCV infection in hepatocytes.Materials and Methods: Induction of IFN-β by LRRFIP1 in Huh7 and Huh7.5.1 was determined by real-time PCR and western blotting in vitro. Inhibition of HCV replication by LRRFIP1 overexpression in hepatocytes was assessed.Results: LRRFIP1 increased the expression of IFN-b in hepatocytes with or without HCV infection. Induction of IFN- b by LRRFIP1 was enhanced with the presence of hepatitis C virus. Overexpression of LRRFIP1 in hepatocytes inhibited HCV replication. However, HCV infection did not regulate intracellular expression of LRRFIP1.Conclusions: LRRFIP1 and its mediated production of type I interferon play a role in controlling HCV infection. The findings of this study provide new target for HCV treatment and contribute to development of anti-HCV drugs.

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APA: Copy

LIU, YUAN, ZOU, ZIYING, ZHU, BING, HU, ZONGHAI, ZENG, PING, & WU, LIJUAN. (2015). LRRFIP1 INHIBITS HEPATITIS C VIRUS REPLICATION BY INDUCING TYPE I INTERFERON IN HEPATOCYTES. HEPATITIS MONTHLY, 15(5), 0-0. SID. https://sid.ir/paper/306877/en

Vancouver: Copy

LIU YUAN, ZOU ZIYING, ZHU BING, HU ZONGHAI, ZENG PING, WU LIJUAN. LRRFIP1 INHIBITS HEPATITIS C VIRUS REPLICATION BY INDUCING TYPE I INTERFERON IN HEPATOCYTES. HEPATITIS MONTHLY[Internet]. 2015;15(5):0-0. Available from: https://sid.ir/paper/306877/en

IEEE: Copy

YUAN LIU, ZIYING ZOU, BING ZHU, ZONGHAI HU, PING ZENG, and LIJUAN WU, “LRRFIP1 INHIBITS HEPATITIS C VIRUS REPLICATION BY INDUCING TYPE I INTERFERON IN HEPATOCYTES,” HEPATITIS MONTHLY, vol. 15, no. 5, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306877/en

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