ASSOCIATION OF TUMOR NECROSIS FACTOR-ALPHA POLYMORPHISMS AND RISK OF CORONARY ARTERY DISEASE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE

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CHENG YUTING; AN BAIQUAN; JIANG MAN; XIN YONGNING; XUAN SHIYING

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Journal: Hepatitis Monthly Year:2015 | Volume:15 | Issue:3 Page(s): 0-0

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Title

ASSOCIATION OF TUMOR NECROSIS FACTOR-ALPHA POLYMORPHISMS AND RISK OF CORONARY ARTERY DISEASE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE

Author(s)

Keywords

TUMOR NECROSIS FACTOR-ALPHA

POLYMORPHISM

GENETIC

NON-ALCOHOLIC FATTY LIVER DISEASE

CORONARY ARTERY DISEASE

Abstract

Background: Cardiovascular events account for the main cause of death in patients with NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD), and are largely influenced by GENETIC factors. Although multiple studies showed that TUMOR NECROSIS FACTOR-ALPHA (TNF-a) POLYMORPHISMs are risk factors in the progression of NAFLD, few papers on the association of the POLYMORPHISMs and the developing CORONARY ARTERY DISEASE (CAD) in NAFLD patients have been reported.Objectives: The present study was designed to evaluate the association of TNF-a POLYMORPHISMs at residues -238 and -308, with the risk of developing CAD in Chinese patients with NAFLD.Patients and Methods: The TNF-a POLYMORPHISMs at residues 238 and 308 were genotyped in B-type ultrasonography proven NAFLD patients with (n=246), without (n=247) CAD and healthy controls (n=304), using polymerase chain reaction (PCR). Serum lipid profiles were determined using biochemical methods. Statistical analyses were performed using SPSS statistical software, version 20.0 for Mac.Results: We found a significant association between TNF-a-238 guanine to alanine (GA) POLYMORPHISM and carriers of variant allele A between NAFLD patients with and without CAD (P<0.05). Carriers of the A allele of TNF-a-238 had higher serum triglycerides (TG) and low density lipoprotein (LDL) levels in NAFLD patients with CAD (P=0.025 and 0.001, respectively) and a higher TG level in NAFLD patients without CAD (P=0.017), than their non-carrier counterparts.Conclusions: In the Chinese Han population that we studied, NAFLD patients who carry the TNF-a-238 GA POLYMORPHISM have an increased risk of developing CAD. Mechanisms underlying this potentially important association require further investigation.

Cites

LEPTIN RECEPTOR GENE POLYMORPHISMS AND THE RISK OF NON-ALCOHOLIC FATTY LIVER DISEASE AND CORONARY ATHEROSCLEROSIS IN THE CHINESE HAN POPULATION

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APA: Copy

CHENG, YUTING, AN, BAIQUAN, JIANG, MAN, XIN, YONGNING, & XUAN, SHIYING. (2015). ASSOCIATION OF TUMOR NECROSIS FACTOR-ALPHA POLYMORPHISMS AND RISK OF CORONARY ARTERY DISEASE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE. HEPATITIS MONTHLY, 15(3), 0-0. SID. https://sid.ir/paper/306902/en

Vancouver: Copy

CHENG YUTING, AN BAIQUAN, JIANG MAN, XIN YONGNING, XUAN SHIYING. ASSOCIATION OF TUMOR NECROSIS FACTOR-ALPHA POLYMORPHISMS AND RISK OF CORONARY ARTERY DISEASE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE. HEPATITIS MONTHLY[Internet]. 2015;15(3):0-0. Available from: https://sid.ir/paper/306902/en

IEEE: Copy

YUTING CHENG, BAIQUAN AN, MAN JIANG, YONGNING XIN, and SHIYING XUAN, “ASSOCIATION OF TUMOR NECROSIS FACTOR-ALPHA POLYMORPHISMS AND RISK OF CORONARY ARTERY DISEASE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE,” HEPATITIS MONTHLY, vol. 15, no. 3, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306902/en

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