AN INDEX TO PREDICT RIBAVIRIN-INDUCED ANEMIA IN ASIAN PATIENTS WITH CHRONIC GENOTYPE 1 HEPATITIS C

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CHEN SHENG HUNG; PENG CHENG YUAN; LAI HSUEH CHOU; SU WEN PANG; LIN CHIA HSIN; LI YU FEN; CHUANG PO HENG; CHEN CHING HSIANG

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Journal: Hepatitis Monthly Year:2015 | Volume:15 | Issue:3 Page(s): 0-0

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Title

AN INDEX TO PREDICT RIBAVIRIN-INDUCED ANEMIA IN ASIAN PATIENTS WITH CHRONIC GENOTYPE 1 HEPATITIS C

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Keywords

POLYMORPHISM

INOSINE TRIPHOSPHATE

HEPATITIS C

RIBAVIRIN

ANEMIA

Abstract

Background: Single-nucleotide POLYMORPHISMs (SNP) in the INOSINE TRIPHOSPHATE pyrophosphatase (ITPA) gene correlate with RIBAVIRIN (RBV)-induced ANEMIA in patients with chronic HEPATITIS C (CHC) receiving combination therapy. Managing ANEMIA is an early priority in the treatment process.Objectives: The aim was to develop a predictive index based on ITPA SNP status to identify CHC patients at risk of ANEMIA.Patients and Methods: A total of 418 eligible East Asian patients diagnosed with CHC genotype 1 (G1) received combination therapy in this study. Participant DNA was genotyped for a functional ITPA SNP (C/C, A/A or C/A) on chromosome 20 at rs1127354. A predictive index was constructed by incorporating independent factors identified for severe ANEMIA events (hemoglobin<10 g/dL). Areas under the receiveroperating characteristic curves (AUCs) represented the diagnostic accuracies of the predictive index in randomly assigned development and validation cohorts.Results: Multiple logistic regressions identified age (≥ 50 y: OR=9.7, 95% CI=5.0- 18.6), ITPA rs1127354 (C/C: OR=3.3, 95% CI=1.8- 5.8) and baseline hemoglobin (<14.0 g/dL: OR 6.4, 95% CI=3.3-12.1; 14.0 - 14.9: OR = 2.4, 95% CI=1.2-4.6) as predictors of severe ANEMIA throughout the treatment. For severe ANEMIA, the predictive index incorporating age, ITPA SNP status and baseline hemoglobin yielded diagnostic accuracies (AUCs) of 0.830 (95% CI=0.783-0.871) in the development (n=324) and 0.902 (0.826-0.925) in the validation (n=81) cohorts.Conclusions: In patients with CHC G1 and receiving combination therapy, ITPA SNP-based index was an accurate and practical solution for prediction of severe ANEMIA.

Cites

THE ITPA AND C20ORF194 POLYMORPHISMS AND HEMATOLOGICAL CHANGES DURING TREATMENT WITH PEGYLATED-INTERFERON PLUS RIBAVIRIN IN PATIENTS WITH CHRONIC HEPATITIS C

References

ASSOCIATION BETWEEN RESPONSE TO PEGYLATED INTERFERON/RIBAVIRIN THERAPY AND RIBAVIRIN LEVELS

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APA: Copy

CHEN, SHENG HUNG, PENG, CHENG YUAN, LAI, HSUEH CHOU, SU, WEN PANG, LIN, CHIA HSIN, LI, YU FEN, CHUANG, PO HENG, & CHEN, CHING HSIANG. (2015). AN INDEX TO PREDICT RIBAVIRIN-INDUCED ANEMIA IN ASIAN PATIENTS WITH CHRONIC GENOTYPE 1 HEPATITIS C. HEPATITIS MONTHLY, 15(3), 0-0. SID. https://sid.ir/paper/306903/en

Vancouver: Copy

CHEN SHENG HUNG, PENG CHENG YUAN, LAI HSUEH CHOU, SU WEN PANG, LIN CHIA HSIN, LI YU FEN, CHUANG PO HENG, CHEN CHING HSIANG. AN INDEX TO PREDICT RIBAVIRIN-INDUCED ANEMIA IN ASIAN PATIENTS WITH CHRONIC GENOTYPE 1 HEPATITIS C. HEPATITIS MONTHLY[Internet]. 2015;15(3):0-0. Available from: https://sid.ir/paper/306903/en

IEEE: Copy

SHENG HUNG CHEN, CHENG YUAN PENG, HSUEH CHOU LAI, WEN PANG SU, CHIA HSIN LIN, YU FEN LI, PO HENG CHUANG, and CHING HSIANG CHEN, “AN INDEX TO PREDICT RIBAVIRIN-INDUCED ANEMIA IN ASIAN PATIENTS WITH CHRONIC GENOTYPE 1 HEPATITIS C,” HEPATITIS MONTHLY, vol. 15, no. 3, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306903/en

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