THE IMPACT OF FRAGILITY FRACTURES ON HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS

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RASZEJA WYSZOMIRSKA JOANNA; KUCHARSKI ROBERT; ZYGMUNT MARTA; SAFRANOW KRZYSZTOF; MIAZGOWSKI TOMASZ

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Journal: Hepatitis Monthly Year:2015 | Volume:15 | Issue:4 Page(s): 0-0

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Title

THE IMPACT OF FRAGILITY FRACTURES ON HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS

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Keywords

HEALTH

QUALITY OF LIFE

OSTEOPOROSIS

CHOLANGITIS

SCLEROSIS

Abstract

Background: OSTEOPOROSIS occurs frequently in patients with chronic cholestatic liver diseases, yet data are scarce regarding the prevalence of OSTEOPOROSIS and fragility fractures and their impact on HEALTH-Related QUALITY OF LIFE (HRQoL) in Primary Sclerosing CHOLANGITIS (PSC).Objectives: We aimed to assess Bone Mineral Density (BMD), physical activity and incidence of fragility fractures in patients with PSC. We also sought associations between prior fractures and HRQoL.Patients and Methods: The study was performed on 33 patients (11 females, 22 males) aged 35.3±13 years. HRQoL was assessed by Short Form (SF)-36, Primary Biliary Cirrhosis (PBC)-40 and PBC-27 questionnaires. BMD was measured by densitometry in the lumbar spine and hip. Physical activity was assessed by questionnaire.Results: In 32% of patients, BMD measured in the hip or spine was below 1.0 Standard Deviation. A history of fragility fractures (distal forearm and ribs) was reported in six patients (18%). In SF-36 assessment, patients with fractures had lower scores in the role functioning, general HEALTH and vitality domains and Physical Component Summary (PCS) than those without fractures. Prior fractures adjusted for gender and PSC duration were associated with lower PCS and Mental Component Summary (MCS) scores. Symptoms and fatigue (assessed by PBC) and prior fractures were inversely associated with MCS (P=0.007).Conclusions: In middle-aged subjects with PSC, we found a high rate of non-vertebral fractures and a moderately decreased BMD in lumbar spine and hip. Fragility fractures had an impact on physical and mental aspects of HRQoL.

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APA: Copy

RASZEJA WYSZOMIRSKA, JOANNA, KUCHARSKI, ROBERT, ZYGMUNT, MARTA, SAFRANOW, KRZYSZTOF, & MIAZGOWSKI, TOMASZ. (2015). THE IMPACT OF FRAGILITY FRACTURES ON HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS. HEPATITIS MONTHLY, 15(4), 0-0. SID. https://sid.ir/paper/306911/en

Vancouver: Copy

RASZEJA WYSZOMIRSKA JOANNA, KUCHARSKI ROBERT, ZYGMUNT MARTA, SAFRANOW KRZYSZTOF, MIAZGOWSKI TOMASZ. THE IMPACT OF FRAGILITY FRACTURES ON HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS. HEPATITIS MONTHLY[Internet]. 2015;15(4):0-0. Available from: https://sid.ir/paper/306911/en

IEEE: Copy

JOANNA RASZEJA WYSZOMIRSKA, ROBERT KUCHARSKI, MARTA ZYGMUNT, KRZYSZTOF SAFRANOW, and TOMASZ MIAZGOWSKI, “THE IMPACT OF FRAGILITY FRACTURES ON HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS,” HEPATITIS MONTHLY, vol. 15, no. 4, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306911/en

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