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Title

NEGATIVE ASSOCIATION OF PLASMA LEVELS OF VITAMIN D AND MIR-378 WITH VIRAL LOAD IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION

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Abstract

 Background: CHRONIC HEPATITIS B (CHB) is accompanied by inflammation of liver because of infection with HEPATITIS B VIRUS (HBV). Previous studies revealed an inverse association between VITAMIN D and HBV DNA levels.Objectives: The current study aimed to investigate the levels of 25 (OH) D3 (the steady form of VITAMIN D), MIR-378 and HBV DNA in the patients with CHB.Patients and Methods: One hundred and seventy three patients with HBeAg negative CHB were recruited for the study. Plasma levels of HBVDNA and 25 (OH) D3 were quantified. The expression level of MIR-378 in plasma was measured by a relative quantitative Real Time Polymerase Chain Reaction (qRT-PCR) assay.Results: In the pathway regression analysis, the plasma level of 25 (OH) D3 showed a significant inverse correlation with plasma levels of HBV DNA (-0.198, P = 0.008) and direct correlation with MIR-378 (0.188, P = 0.013). Similarly plasma level of MIR-378 had inverse association with HBV DNA level (-0.177, P = 0.020).Conclusions: These results suggest that VITAMIN D could involve in a miRNA- mediated regulatory pathway in control of HBV replication. Further studies are recommended to understand the effects of MIR-378 and anti-infective action of VITAMIN D on HEPATITIS B VIRUS.

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    APA: Copy

    MOHAMADKHANI, ASHRAF, BASTANI, FAEGH, KHORRAMI, SAMANEH, GHANBARI, REZA, SHARAFKHAH, MARYAM, MONTAZERI, GHODRATOLLAH, & POUSTCHI, HOSSEIN. (2015). NEGATIVE ASSOCIATION OF PLASMA LEVELS OF VITAMIN D AND MIR-378 WITH VIRAL LOAD IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION. HEPATITIS MONTHLY, 15(6), 0-0. SID. https://sid.ir/paper/306940/en

    Vancouver: Copy

    MOHAMADKHANI ASHRAF, BASTANI FAEGH, KHORRAMI SAMANEH, GHANBARI REZA, SHARAFKHAH MARYAM, MONTAZERI GHODRATOLLAH, POUSTCHI HOSSEIN. NEGATIVE ASSOCIATION OF PLASMA LEVELS OF VITAMIN D AND MIR-378 WITH VIRAL LOAD IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION. HEPATITIS MONTHLY[Internet]. 2015;15(6):0-0. Available from: https://sid.ir/paper/306940/en

    IEEE: Copy

    ASHRAF MOHAMADKHANI, FAEGH BASTANI, SAMANEH KHORRAMI, REZA GHANBARI, MARYAM SHARAFKHAH, GHODRATOLLAH MONTAZERI, and HOSSEIN POUSTCHI, “NEGATIVE ASSOCIATION OF PLASMA LEVELS OF VITAMIN D AND MIR-378 WITH VIRAL LOAD IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION,” HEPATITIS MONTHLY, vol. 15, no. 6, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306940/en

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