CORRELATION OF HISTOPATHOLOGIC FINDINGS OF NON-GRAFT THREATENING PRESERVATION/REPERFUSION INJURY IN TIME-ZERO LIVER NEEDLE BIOPSIES WITH SHORT-TERM POST-TRANSPLANTATION LABORATORY ALTERATIONS

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SHAHBAZI NARGES; HAERI HAYEDEH; NASIRI TOOSI MOHSEN; JAFARIAN ALI; SHAHSIAH REZA; TALEBIAN MOGHADAM MONAVAR; S. POURSALEH SEDIGHEH; AZMOUDEH ARDALAN FARID

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Journal: Hepatitis Monthly Year:2015 | Volume:15 | Issue:6 Page(s): 0-0

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Title

CORRELATION OF HISTOPATHOLOGIC FINDINGS OF NON-GRAFT THREATENING PRESERVATION/REPERFUSION INJURY IN TIME-ZERO LIVER NEEDLE BIOPSIES WITH SHORT-TERM POST-TRANSPLANTATION LABORATORY ALTERATIONS

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Keywords

ISCHEMIA REPERFUSION INJURY

LIVER FUNCTION TESTS

PATHOLOGY

LIVER TRANSPLANTATION

Abstract

Background: Early post-transplantation alterations in liver tests are caused by a variety of etiologies including rejection, biliary or vascular complications, and preservation/reperfusion injury (PRI).Objectives: The aim of this study was to show the correlation between histopathologic changes of PRI and the alterations in liver tests in the early post-transplantation period.Materials and Methods: Between April 2013 and August 2014, histopathologic findings of protocol, time-zero, Tru-Cut, liver needle biopsies were evaluated in 94 cases of cadaveric LIVER TRANSPLANTATION. The histopathologic changes included ballooning degeneration, micro- and macro-vesicular steatosis, bilirubin ostasis, apoptotic cells, bile plugs and neutrophilic infiltration. These histopathologic changes were compared with the early (15 days) post-transplantation liver laboratory findings.Results: Clinico-pathologic evaluation of all 94 cases was done by assessment of PRI findings in time-zero biopsies and possible causes of allograft injury were appraised. In 21 patients, a specific cause for allograft injury was found including rejection and/or surgical complications. In the remaining 73 cases, there was no specific cause for allograft injury and histopathologic findings of time-zero liver needle biopsies supported PRI. We classified liver laboratory tests alterations as: hepatocellular damage (elevation of transaminases and lactate dehydrogenase), cholestatic damage (elevation of alkaline phosphatase and total bilirubin) and mixed. Hepatocellular and cholestatic alterations in LIVER FUNCTION TESTS were associated with the presence of marked apoptotic bodies and neutrophilic aggregates in time zero biopsies, respectively. On the other hand, macro vesicular steatosis was dominantly associated with mixed (hepatocellular and cholestatic) laboratory alterations of liver tests.Conclusions: Any discrepancy between histopathologic changes in time-zero biopsies and pattern of early liver laboratory alterations may be considered as a warning for causes other than PRI.

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APA: Copy

HAERI, HAYEDEH, NASIRI TOOSI, MOHSEN, JAFARIAN, ALI, SHAHSIAH, REZA, TALEBIAN MOGHADAM, MONAVAR, S. POURSALEH, SEDIGHEH, & AZMOUDEH ARDALAN, FARID. (2015). CORRELATION OF HISTOPATHOLOGIC FINDINGS OF NON-GRAFT THREATENING PRESERVATION/REPERFUSION INJURY IN TIME-ZERO LIVER NEEDLE BIOPSIES WITH SHORT-TERM POST-TRANSPLANTATION LABORATORY ALTERATIONS. HEPATITIS MONTHLY, 15(6), 0-0. SID. https://sid.ir/paper/306941/en

Vancouver: Copy

HAERI HAYEDEH, NASIRI TOOSI MOHSEN, JAFARIAN ALI, SHAHSIAH REZA, TALEBIAN MOGHADAM MONAVAR, S. POURSALEH SEDIGHEH, AZMOUDEH ARDALAN FARID. CORRELATION OF HISTOPATHOLOGIC FINDINGS OF NON-GRAFT THREATENING PRESERVATION/REPERFUSION INJURY IN TIME-ZERO LIVER NEEDLE BIOPSIES WITH SHORT-TERM POST-TRANSPLANTATION LABORATORY ALTERATIONS. HEPATITIS MONTHLY[Internet]. 2015;15(6):0-0. Available from: https://sid.ir/paper/306941/en

IEEE: Copy

HAYEDEH HAERI, MOHSEN NASIRI TOOSI, ALI JAFARIAN, REZA SHAHSIAH, MONAVAR TALEBIAN MOGHADAM, SEDIGHEH S. POURSALEH, and FARID AZMOUDEH ARDALAN, “CORRELATION OF HISTOPATHOLOGIC FINDINGS OF NON-GRAFT THREATENING PRESERVATION/REPERFUSION INJURY IN TIME-ZERO LIVER NEEDLE BIOPSIES WITH SHORT-TERM POST-TRANSPLANTATION LABORATORY ALTERATIONS,” HEPATITIS MONTHLY, vol. 15, no. 6, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306941/en

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