PREDICTORS OF PEGYLATED INTERFERON ALPHA AND RIBAVIRIN EFFICACY AND LONG-TERM ASSESSMENT OF RELAPSE IN PATIENTS WITH CHRONIC HEPATITIS C: A ONE-CENTER EXPERIENCE FROM CHINA

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WU QIN; ZHAN FENG YU; CHEN EN QIANG; WANG CONG; LI ZHEN ZHEN; LEI XUE ZHONG

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Journal: Hepatitis Monthly Year:2015 | Volume:15 | Issue:6 Page(s): 0-0

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Title

PREDICTORS OF PEGYLATED INTERFERON ALPHA AND RIBAVIRIN EFFICACY AND LONG-TERM ASSESSMENT OF RELAPSE IN PATIENTS WITH CHRONIC HEPATITIS C: A ONE-CENTER EXPERIENCE FROM CHINA

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Keywords

HEPATITIS C

CHRONIC

FOLLOW-UP STUDIES

RECURRENCE

INTERFERON

Abstract

Background: Sustained virological response (SVR) and virological relapse maintain pivotal roles in the management of CHRONIC HEPATITIS C (CHC); however, there is little data regarding the long-term outcomes of patients with CHC in China.Objectives: We aimed to investigate the predictive factors of therapeutic effect and viral relapse in patients who achieved end-of-treatment response (ETR).Patients and Methods: We retrospectively analyzed clinical, biochemical and virological data of 169 adult patients with CHC from China who were not treated with pegylated INTERFERON-alpha (PEG IFN-a) and ribavirin, of which 142 achieved ETR and with a follow-up period ranging from six months to six years. Statistical analysis was performed by SPSS 20.0.Results: Of the 169 patients, 124 (73.4%) achieved SVR and 23 (16.2%) experienced relapses post-therapy in cases of ETR patients. We considered sex, age, alanine aminotransferase, aspartate transaminase, baseline HEPATITIS C virus RNA level, HCV genotypes, IL28B rs12979860 genotype, rapid virological response (RVR), and early virological response (EVR). For antiviral effect in patients with CHC, HCV genotypes (2, 3) (c2 = 11.285, P = 0.001), IL28B genotype (rs12979860 CC) (c2 = 16.552, P < 0.001), RVR (c2 = 37.339, P < 0.001), and EVR (c2 = 70.265, P < 0.001) were significantly correlated with achieving SVR. For ETR patients with long-term follow-up, the relapse rate within six months was significantly higher than within other periods during six-year follow-up (c2 = 7.792, P = 0.005). Relapse was virtually not observed after therapy ceased for 48 weeks. The IL28B genotype (rs12979860 CT/TT) (OR = 0.102; 95% CI, 0.031-0.339; P < 0.001), lower RVR (OR = 0.239; 95% CI, 0.078-0.738; P = 0.013), and EVR (OR = 0.102; 95% CI, 0.016-0.661; P = 0.017) were independent risk factors for relapse.Conclusions: Our study comprehensively explored the predictive factors of therapeutic effect of administered drugs and analyzed viral relapse during a six-months to six-year follow-up period from China. The SVR may not be the perfect endpoint of HCV therapy in Chinese people; we recommend 48 weeks after treatment withdrawal as the suitable time point.

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APA: Copy

WU, QIN, ZHAN, FENG YU, CHEN, EN QIANG, WANG, CONG, LI, ZHEN ZHEN, & LEI, XUE ZHONG. (2015). PREDICTORS OF PEGYLATED INTERFERON ALPHA AND RIBAVIRIN EFFICACY AND LONG-TERM ASSESSMENT OF RELAPSE IN PATIENTS WITH CHRONIC HEPATITIS C: A ONE-CENTER EXPERIENCE FROM CHINA. HEPATITIS MONTHLY, 15(6), 0-0. SID. https://sid.ir/paper/306942/en

Vancouver: Copy

WU QIN, ZHAN FENG YU, CHEN EN QIANG, WANG CONG, LI ZHEN ZHEN, LEI XUE ZHONG. PREDICTORS OF PEGYLATED INTERFERON ALPHA AND RIBAVIRIN EFFICACY AND LONG-TERM ASSESSMENT OF RELAPSE IN PATIENTS WITH CHRONIC HEPATITIS C: A ONE-CENTER EXPERIENCE FROM CHINA. HEPATITIS MONTHLY[Internet]. 2015;15(6):0-0. Available from: https://sid.ir/paper/306942/en

IEEE: Copy

QIN WU, FENG YU ZHAN, EN QIANG CHEN, CONG WANG, ZHEN ZHEN LI, and XUE ZHONG LEI, “PREDICTORS OF PEGYLATED INTERFERON ALPHA AND RIBAVIRIN EFFICACY AND LONG-TERM ASSESSMENT OF RELAPSE IN PATIENTS WITH CHRONIC HEPATITIS C: A ONE-CENTER EXPERIENCE FROM CHINA,” HEPATITIS MONTHLY, vol. 15, no. 6, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306942/en

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